SFRP4 gene expression is increased in aggressive prostate cancer

Scientific Reports
Elise SandsmarkMay-Britt Tessem

Abstract

Increased knowledge of the molecular differences between indolent and aggressive prostate cancer is needed for improved risk stratification and treatment selection. Secreted frizzled-related protein 4 (SFRP4) is a modulator of the cancer-associated Wnt pathway, and previously suggested as a potential marker for prostate cancer aggressiveness. In this study, we investigated and validated the association between SFRP4 gene expression and aggressiveness in nine independent cohorts (n = 2157). By differential expression and combined meta-analysis of all cohorts, we detected significantly higher SFRP4 expression in cancer compared with normal samples, and in high (3-5) compared with low (1-2) Grade Group samples. SFRP4 expression was a significant predictor of biochemical recurrence in six of seven cohorts and in the overall analysis, and was a significant predictor of metastatic event in one cohort. In our study cohort, where metabolic information was available, SFRP4 expression correlated significantly with the concentrations of citrate and spermine, two previously suggested biomarkers for aggressive prostate cancer. SFRP4 immunohistochemistry in an independent cohort (n = 33) was not associated with aggressiveness. To conclude, h...Continue Reading

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Citations

Jun 19, 2018·Expert Review of Molecular Diagnostics·Alessia CimadamoreRodolfo Montironi
Oct 23, 2019·International Journal of Oncology·Xiaozeng LinDamu Tang
Sep 15, 2020·Journal of Proteome Research·Nuria Gómez-CebriánLeonor Puchades-Carrasco

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Methods Mentioned

BETA
biopsy
PCR
biopsies
Chip

Software Mentioned

R
SPSS
LCModel
metafor

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