SGLT1 inhibition: Pros and cons

European Journal of Pharmacology
V TsimihodimosM S Elisaf

Abstract

Sodium Glucose Cotransporters 1 (SGLT1) play important roles in the intestinal absorption of glucose and the renal reabsorption of glucose, especially in patients with uncontrolled diabetes and those receiving SGLT2 inhibitors. As a consequence, the inhibition of SGLT1 transporters may represent an interesting therapeutic option in patients with diabetes. However, genetic models of SGLT1 inactivation indicate that the malfunction of these transporters may have adverse effects on various tissues. In this review, we discuss the available evidence on the beneficial and detrimental effects that the inhibition of SGLT1 transporters might have. The inhibition of SGLT1 lowers serum glucose levels through the inhibition of intestinal absorption and renal reabsorption of glucose. In addition, drugs that interfere with SGLT1-mediated transport of glucose may protect cardiac tissue by reducing glycogen accumulation and decreasing the production of reactive oxygen species. On the other hand, this strategy may result in diarrhea, volume depletion, may interfere with the correction of hypoglycemia through the oral administration of carbohydrates and could predispose to the development of euglycemic diabetic ketoacidosis. Therefore, at the mo...Continue Reading

Citations

Aug 7, 2019·Pharmacology Research & Perspectives·Paul OranjeGerard J P van Westen
Mar 15, 2019·Journal of the American Society of Nephrology : JASN·Mattias Carlström
Feb 13, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pantelis SarafidisMads Hornum
Feb 5, 2021·Future Cardiology·Vivencio Barrios, Carlos Escobar
Jan 9, 2021·Cardiovascular Diabetology·David BodeFelix Hohendanner
Nov 17, 2020·Journal of the American Heart Association·Edoardo GrondaClaudio Napoli
Mar 9, 2021·British Journal of Clinical Pharmacology·Theocharis KoufakisKalliopi Kotsa
Jul 18, 2020·Current Topics in Medicinal Chemistry·Worood Sirhan, Ron Piran

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