SGLT6 - A pharmacological target for the treatment of obesity?

Adipocyte
Tamara Baader-PaglerBradford S Hamilton

Abstract

Despite increased knowledge of nutrient intake regulation and energy homeostasis, treatment options for obesity remain limited. Food reward consists of two branches: gustatory and post-ingestive nutritive information. Drosophila lacking dSLC5A11 (sodium/glucose cotransporter 6-SGLT6) prefer L-glucose over D-glucose independently of their state of satiety. Human SGLT6 is an active transporter of myo-inositol and D-glucose. We investigated expression of SGLT6 in human tissue and found a significant expression in the small intestine and brain. The preference between a metabolizable and a non-metabolizable sugar was tested in 3 mouse models with a selective and potent SGLT6 inhibitor. No influence on sugar preference was seen with SGLT6 inhibition. These studies suggest that SGLT6 does not play a significant role in nutrient sensing in mammals.

References

Jul 23, 2002·The Journal of Biological Chemistry·Michael J CoadyJean-Yves Lapointe
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Katherine M FlegalClifford L Johnson
Nov 30, 2006·Diabetes·Dervla O'MalleyFiona M Gribble
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul S MacleanMatthew R Jackman
Nov 15, 2011·Nature Neuroscience·Ana I DomingosJeffrey Friedman
Dec 1, 2011·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Jian ChenJohn N Feder
Sep 7, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ryota KikuchiJ Cory Kalvass
Feb 26, 2015·Chemical Senses·Anthony SclafaniKaren Ackroff
Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
May 10, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P SiegerS Scheuerer

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Citations

Aug 9, 2020·Pflügers Archiv : European journal of physiology·Gergely GyimesiMatthias A Hediger
Jul 8, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Hans-Rudolf BerthoudAnthony Sclafani

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Methods Mentioned

BETA
equilibrium dialysis

Software Mentioned

AxioVision
EthoVision© XT
ToxKin®

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