PMID: 7542925Jul 28, 1995Paper

SH2 domain structure and function

Biochimica Et Biophysica Acta
B Schaffhausen

Abstract

An emerging theme in both the biology of signal transduction and the biochemistry of proteins has been the modular function of small protein domains. In some cases these can directly regulate catalytic activity. In others, they serve to interconnect important regulatory proteins. SH2 (src homology 2) domains represent some of the best studied models. Originally identified on the basis of homology in src and fps [1], SH2s are elements that ordinarily respond to tyrosine phosphorylation by binding the phosphorylated sequence. As such, they are key elements in tyrosine kinase regulation of cellular processes. Because SH2 interactions result from phosphorylation, such elements provide a regulatable circuitry along which signals can be transmitted in a timely manner. Because the regulation is based on a common mechanism, signal generators can target several different proteins coordinately. The PDGF receptor (PDGFr), for example, may interact with as many as ten different elements [2,3]. There are a number of excellent reviews on SH2 domains available [4-11]. This discussion will try to show how genetic, biochemical and biophysical results can be integrated in a satisfying way.

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Citations

Sep 23, 1997·Protein Science : a Publication of the Protein Society·A U Singer, J D Forman-Kay
Jun 1, 1996·Cancer Metastasis Reviews·K P Claffey, G S Robinson
Oct 3, 2003·Biochemical and Biophysical Research Communications·Ya-Qiu LongPeter P Roller
Oct 30, 2001·Critical Reviews in Oncology/hematology·M VidalC Garbay
Jun 2, 2005·Science's STKE : Signal Transduction Knowledge Environment·Feng Qiao, James U Bowie
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·C BéraudP A Baeuerle
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·James M Samet, Tamara L Tal
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May 28, 1998·The Journal of Biological Chemistry·J D AllardM A Simon
Sep 5, 1997·The Journal of Biological Chemistry·M Y KanemitsuW Eckhart
Oct 3, 1999·The Journal of Biological Chemistry·E L Snapp, S M Landfear
Nov 29, 2002·Protein Engineering·Fabrizio Giordanetto, Romano T Kroemer
Jun 13, 2020·Frontiers in Molecular Biosciences·Lorenzo ViscontiStefano Gianni
Oct 13, 2020·Frontiers in Endocrinology·Rachel Jaber Chehayeb, Titus J Boggon
Aug 19, 2020·Journal of Chemical Theory and Computation·Nuno F B OliveiraMiguel Machuqueiro

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