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Shadow enhancers enable Hunchback bifunctionality in the Drosophila embryo

bioRxiv

Aug 13, 2014

Max V StallerAngela H. DePace

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Abstract

Hunchback (Hb) is a bifunctional transcription factor that activates and represses distinct enhancers. Here, we investigate the hypothesis that Hb can activate and repress the same enhancer. Computational models predicted that Hb bifunctionally regulates the even-skipped (eve) stripe 3+...read more

Mentioned in this Paper

Blastoderm
Drosophila
Embryo
Embryonic Development
Gene Expression
Genes
Genome
Hemoglobin
Kyphosis Deformity of Spine
Transcription Factor
12
29
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  • Shadow enhancers enable Hunchback bifunctionality in the Drosophila embryo

    bioRxiv

    Aug 13, 2014

    Max V StallerAngela H. DePace

    PMID: 990007922

    DOI: 10.1101/007922

    Abstract

    Hunchback (Hb) is a bifunctional transcription factor that activates and represses distinct enhancers. Here, we investigate the hypothesis that Hb can activate and repress the same enhancer. Computational models predicted that Hb bifunctionally regulates the even-skipped (eve) stripe 3+...read more

    Mentioned in this Paper

    Blastoderm
    Drosophila
    Embryo
    Embryonic Development
    Gene Expression
    12
    29

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