Shaker K+ channels contribute early nonlinear amplification to the light response in Drosophila photoreceptors

Journal of Neurophysiology
Mikko JuusolaAndrew S French

Abstract

We describe the contribution of rapidly inactivating Shaker K+ channels to the dynamic membrane properties of Drosophila photoreceptors. Phototransduction was measured in wild-type and Shaker mutant (Sh14) Drosophila photoreceptors by stimulating with white noise-modulated light contrast and recording the resulting intracellular membrane potential fluctuations. A second-order Volterra kernel series was used to characterize the nonlinear dynamic properties of transduction in the two situations. First-order kernels were indistinguishable in wild-type and Sh14 photoreceptors, indicating that the basic light transduction machinery was always intact. However, second-order kernels of Shaker mutants lacked a large, early amplification, indicating a novel role for Shaker K+ channels in amplifying and accelerating the voltage response of wild-type photoreceptors. A cascade model of two nonlinear static components surrounding one linear dynamic component was able to partially reproduce the experimental responses. Parameters obtained by fitting the model to the experimental data supported the hypothesis that normal Shaker K+ channels contribute an early, positive nonlinearity that partially offsets a later attenuating nonlinearity caused ...Continue Reading

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Citations

Mar 6, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Julia SchuckelAndrew S French
Mar 16, 2006·Annals of Biomedical Engineering·James R Green, Michael J Korenberg
May 15, 2008·PloS One·Olivier Faivre, Mikko Juusola
Feb 16, 2005·IEEE Transactions on Bio-medical Engineering·Musa H Asyali, Mikko Juusola
Mar 11, 2008·Current Biology : CB·Rikard FrederiksenEric J Warrant
Nov 9, 2016·Frontiers in Physiology·Andrew S FrenchRoman V Frolov
Jul 28, 2018·The Journal of General Physiology·Roman V Frolov
Dec 12, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Burak GürMarion Silies
Jan 8, 2010·Journal of Neurophysiology·Joshua P van KleefMichael R Ibbotson
May 21, 2008·The Journal of Experimental Biology·Jeremy E Niven, Simon B Laughlin

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