Shaker-type potassium channel subunits differentially control oligodendrocyte progenitor proliferation

Glia
François VautierV Gallo

Abstract

Oligodendrocyte precursor (OP) cells are exposed to multiple extrinsic signals that control their proliferation and differentiation. Previous cell proliferation studies and electrophysiological analysis in cultured cells and in brain slices have suggested that outward potassium channels, particularly Kv1 subunits, may have a prominent role in OP cell proliferation. In the present study, we assessed to what extent overexpression of Kv1.3, Kv1.4, Kv1.5, and Kv1.6 can affect OP cell proliferation and differentiation in culture. We observed that overexpression of Kv1.3 or Kv1.4 increased OP cell proliferation in the absence of mitogens, whereas Kv1.6 overexpression inhibited mitogen-induced OP cell cycle progression. Interestingly, Kv1.3, Kv1.4, Kv1.5, and Kv1.6 overexpression did not interfere with the kinetics of oligodendrocyte differentiation. This study represents the first demonstration that the activity of potassium channels containing distinct Kv1 subunit proteins directly controls oligodendroglial proliferation in the presence of mitogens, as well as in growth factor-free conditions.

References

Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Dec 1, 1993·Trends in Pharmacological Sciences·K G Chandy, G A Gutman
Jan 1, 1993·Progress in Biophysics and Molecular Biology·J M Dubois, B Rouzaire-Dubois
Nov 1, 1996·The Journal of Membrane Biology·W F Wonderlin, J S Strobl
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Jun 29, 2000·Trends in Pharmacological Sciences·V Gallo, C A Ghiani
Jan 5, 2002·Developmental Neuroscience·S BelachewV Gallo
Jan 17, 2002·The Journal of Comparative Neurology·Lori EdwardsMichael G Fehlings
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·R ChittajalluV Gallo

❮ Previous
Next ❯

Citations

Feb 27, 2008·Journal of Molecular Neuroscience : MN·Gunnar JeserichMelanie Pfeiffer
Nov 28, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew D Goodman, Robert Thompson Stone
Dec 23, 2006·Journal of Neurotrauma·Judith M LytleJean R Wrathall
Feb 22, 2012·Human Molecular Genetics·Jie LuVolney Sheen
May 29, 2008·Clinical and Experimental Pharmacology & Physiology·Shao-Ping WangHai Wang
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert A HillAkiko Nishiyama
Dec 5, 2015·Expert Opinion on Therapeutic Targets·Mireia Pérez-VerdaguerAntonio Felipe
Jun 23, 2009·Expert Opinion on Therapeutic Targets·Srikant RangarajuK George Chandy
Dec 17, 2014·Expert Opinion on Drug Metabolism & Toxicology·Alessandra Lugaresi
Jun 12, 2012·Trends in Neurosciences·Stacey Watkins, Harald Sontheimer
Jul 12, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Carmen Espejo, Xavier Montalban
May 5, 2011·Experimental and Molecular Pathology·Cosmin A TeglaHorea Rus
Jul 15, 2009·Journal of Neuroscience Methods·Roeland BuckinxJean-Michel Rigo
Oct 13, 2006·Journal of Neurochemistry·Stefan LiebauOliver H Wittekindt
Sep 19, 2007·Glia·Haruki Higashimori, Harald Sontheimer
May 20, 2011·Journal of Anatomy·Nicole FröhlichMaria Kukley
Sep 15, 2006·Cancer Detection and Prevention·Antonio FelipeEnric Condom
May 2, 2006·Biochemical and Biophysical Research Communications·Haiyan LiuJohn J Enyeart
Oct 20, 2006·Neuroscience·R Káradóttir, D Attwell
Jan 31, 2008·Biochimica Et Biophysica Acta·Núria VillalongaAntonio Felipe
Nov 12, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Christine Beeton, K George Chandy
Sep 22, 2006·Nature Reviews. Neuroscience·Leonard K Kaczmarek
Dec 15, 2015·The Journal of Biological Chemistry·Laura Jiménez-PérezM Teresa Pérez-García
Sep 22, 2017·American Journal of Physiology. Cell Physiology·M Teresa Pérez-GarcíaJosé R López-López
Oct 11, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Marycarmen Arévalo-MartínezM Teresa Pérez-García
Nov 28, 2016·Molecular Neurobiology·Shirin KashfiMohammad Javan
Nov 8, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·José R López-LópezM Teresa Pérez-García
Feb 12, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yasmine KamenRagnhildur T Káradóttir
Jan 30, 2021·Neural Regeneration Research·Federica CherchiElisabetta Coppi
Jan 1, 2021·Frontiers in Cell and Developmental Biology·Magdalena BachmannErich Gulbins
May 2, 2021·Medicinal Research Reviews·Špela GubičLucija P Mašič

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.