Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia

Gynecologic Oncology
Jerome L BelinsonD Zahniser

Abstract

The aim of this study was to design a cervical cancer screening algorithm for the developing world that is highly sensitive for cervical intraepithelial neoplasia (CIN) II, III, and cancer and highly specific for CIN II and III, making it possible to ablate the transformation zone without histologic confirmation. In rural Shanxi Province, China, we examined 1997 women ages 35-45. Each subject underwent a self-test for intermediate and high-risk HPV (by HC-II assay), fluorescence spectroscopy, a liquid-based Pap (read manually and by computer and used as a direct test for HPV), a visual inspection (VIA) diagnosis, and colposcopy with multiple cervical biopsies. Mean age was 39.1 +/- 3.16 years, mean number of births was 2.6 +/- 0.93. Based on tests administered, 4.3% subjects had > or =CIN II. All subjects with > or =CIN II had either a ThinPrep Pap (> or =ASCUS) or a positive HPV direct test. The sensitivity and specificity for the detection of > or =CIN II were, respectively, 83 and 86% for the HPV self-test, 95 and 85% for the HPV direct test, 94 and 78% for the ThinPrep Pap (> or =ASCUS), 77 and 98% for the ThinPrep Pap (> or =HGSIL), 94 and 9% for fluorescence spectroscopy, 71 and 74% for VIA, and 81 and 77% for colposcopy....Continue Reading

References

Jul 1, 1989·Medical Decision Making : an International Journal of the Society for Medical Decision Making·D K McClish
Sep 1, 1996·Obstetrics and Gynecology·E MegevandB Bloch
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J BlackD M Parkin
Aug 7, 1999·Lancet·M E Adams
Jan 13, 2000·JAMA : the Journal of the American Medical Association·M SchiffmanA T Lorincz
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J. BelinsonX. P. Yang

❮ Previous
Next ❯

Citations

Mar 1, 2011·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Shang-Ying HuYou-Lin Qiao
Oct 17, 2003·The New England Journal of Medicine·George F SawayaA Eugene Washington
Oct 19, 2007·The New England Journal of Medicine·Marie-Hélène MayrandUNKNOWN Canadian Cervical Cancer Screening Trial Study Group
Nov 18, 2005·The New England Journal of Medicine·Sue J GoldieUNKNOWN Alliance for Cervical Cancer Prevention Cost Working Group
Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick PetignatUNKNOWN Canadian Women's HIV Study Group
May 17, 2008·American Journal of Epidemiology·Jill KoshiolJennifer S Smith
Apr 22, 2004·Journal of the National Cancer Institute·Sue J GoldieEduardo Franco
Jan 25, 2012·Journal of the National Cancer Institute·Fang-Hui ZhaoPhilip E Castle
Jan 29, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Kayode Olusegun AjenifujaMark Schiffman
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J L BelinsonD Fife
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J MonsonegoE Franco
Aug 1, 2007·BMC Medical Research Methodology·Lynne GaffikinPaul D Blumenthal
Jun 22, 2012·BMC Infectious Diseases·Jia JiYou-Lin Qiao
Aug 5, 2006·Cost Effectiveness and Resource Allocation : C/E·Jeremy D Goldhaber-Fiebert, Sue J Goldie
Mar 8, 2013·Lasers in Medical Science·Sanaz Hariri TabriziHenricus J C M Sterenborg
Jan 15, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·D RiethmullerC Mougin
Feb 2, 2006·American Journal of Public Health·Eric J SubaStephen S Raab
Mar 5, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Shao-Ming WangYou-Lin Qiao
Sep 5, 2002·Cancer·Andrew A Renshaw
Apr 26, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H De VuystM Temmerman
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S AbdulJ A Tidy
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P F EscobarJ L Belinson
Feb 7, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Reem A MustafaHolger J Schünemann
Nov 14, 2002·American Journal of Clinical Pathology·Diane D DaveyUNKNOWN American Society for Colposcopy and Cervical Pathology
Oct 1, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jennifer S SmithJeanne M Pimenta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.