Shape analysis of the corpus callosum and cerebellum in female MS patients with different clinical phenotypes

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Deniz SigirliOmer Faruk Turan

Abstract

The aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients compared with healthy controls. This study was conducted using the magnetic resonance imaging scans of 15 control subjects, 26 RRMS, and 14 SPMS patients. The data obtained from the landmark coordinates were analyzed with statistical shape analysis. The landmarks that were chosen to determine the shape differences of the CC and cerebellum have been identified and used in previous studies. In addition to these landmarks, constructed landmarks were determined and used to assess regional shape differences better. The shapes of the CC and cerebellum showed statistically significant differences from the controls when compared with both the RRMS and SPMS patients. It was found that the deformation observed from controls to SPMS was greater than the deformation from controls to RRMS, both for the CC and cerebellum. In conclusion, this study revealed CC and cerebellar shape change in RRMS and SPMS, and showed that deformations both in CC and cerebellum advances with the disease progression.

References

Dec 11, 1992·Brain Research·F AboitizE Zaidel
Oct 20, 1998·Biological Psychiatry·P TibboN C Andreasen
Jun 1, 1999·Biological Psychiatry·J R DeQuardoJ W Pettegrew
Dec 17, 2002·NeuroImage·Ronald PiersonNancy C Andreasen
Sep 29, 2004·Medical Image Analysis·Martin StynerGuido Gerig
Jan 18, 2006·Brain : a Journal of Neurology·Christian Confavreux, Sandra Vukusic
May 12, 2007·Brain Pathology·Alexandra KutzelniggHans Lassmann
Jun 1, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Senem Turan OzdemirCagatay Barut
Nov 16, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Omer IshaqAnthony Traboulsee
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Feb 10, 2009·Journal of the Neurological Sciences·Deepa Preeti RamasamyRobert Zivadinov
Apr 1, 2009·Anatomical Science International·Fusun SonatBehzat Noyan
May 26, 2009·Multiple Sclerosis : Clinical and Laboratory Research·V M AndersonD H Miller
Jun 23, 2009·Journal of Anatomy·Seth M WeinbergPeg Nopoulos
Dec 8, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Massimiliano CalabresePaolo Gallo
Feb 16, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Catherine J Stoodley, Jeremy D Schmahmann
Apr 2, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cemil ColakAlpay Alkan
Jun 1, 2011·Acta Neuropathologica·Richard ReynoldsOwain Howell
Sep 29, 2011·Investigative Ophthalmology & Visual Science·Patrick SibonyF James Rohlf

❮ Previous
Next ❯

Citations

Sep 4, 2015·Acta neurochirurgica·Gokhan OcakogluIbrahim Bora
Jun 5, 2020·Neurological Research·Deniz SigirliBasak Erdemli Gursel
Feb 16, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael PlattenTobias Granberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Pediatric Otorhinolaryngology
Bradley B Block, Linda Brodsky
Annals of Emergency Medicine
S J Sainsbury
Folia phoniatrica
N IsshikiM Morimoto
International Journal of Pediatric Otorhinolaryngology
Karen B ZurLinda Lee
Anatomical Science International
Fusun SonatBehzat Noyan
© 2021 Meta ULC. All rights reserved