Shape analysis of the middle cranial fossa of schizophrenic patients. A computerized tomographic study

Schizophrenia Research
M F CasanovaD R Weinberger

Abstract

Recent morphometric studies indicate that both right and left temporal lobe volumes are reduced in schizophrenic patients. Subsequent studies suggested that this volumetric reduction is the result of focal or multifocal gray matter abnormalities. Since in early life brain growth or lack thereof influences the overlying skull configuration, we attempted to elucidate the time of onset of the temporal lobe lesion in schizophrenic patients by quantifying both the volume and shape of their middle cranial fossa. Computerized tomographic scans of 17 schizophrenic patients and an equal number of age-matched controls were digitized using a LOATS image analysis system. The middle cranial fossa was manually outlined and software routines allowed the quantification of volume and shape parameters. Our results showed that no significant differences were present between schizophrenic patients and controls. If the bilateral reduction in temporal lobe volumes in schizophrenic patients is the result of an early onset (e.g., developmental) lesion, the resultant foci of gray matter abnormality may occur distant to the base of the skull. Alternatively, tissue loss may be insufficient to alter the development of the overlying skull or to be detected...Continue Reading

Citations

Feb 1, 1990·Biological Psychiatry·M F Casanova, J E Kleinman
Apr 15, 1991·Biological Psychiatry·D G DanielD R Weinberger
Sep 21, 2001·Journal of Neuroscience Methods·M F CasanovaB Pourdihimi
Feb 8, 2013·Brain : a Journal of Neurology·Kathrin C ZierhutKolja Schiltz
Feb 15, 2011·NeuroImage·Rachel A YotterChristian Gaser
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Oct 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·Ben A WeissmanMatthew P Hardy
Jan 1, 1997·European Psychiatry : the Journal of the Association of European Psychiatrists·V OlivierJ Chevalier
Jun 7, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Kathrin NickelSimon Maier
Apr 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·T F McNeilT Rosenlund
Jun 1, 2010·Translational Neuroscience·Manuel F CasanovaAndrew E Switala

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