Shape-changing magnetic assemblies as high-sensitivity NMR-readable nanoprobes

Nature
Gary ZabowAlan Koretsky

Abstract

Fluorescent and plasmonic labels and sensors have revolutionized molecular biology, helping visualize cellular and biomolecular processes. Increasingly, such probes are now being designed to respond to wavelengths in the near-infrared region, where reduced tissue autofluorescence and photon attenuation enable subsurface in vivo sensing. But even in the near-infrared region, optical resolution and sensitivity decrease rapidly with increasing depth. Here we present a sensor design that obviates the need for optical addressability by operating in the nuclear magnetic resonance (NMR) radio-frequency spectrum, where signal attenuation and distortion by tissue and biological media are negligible, where background interferences vanish, and where sensors can be spatially located using standard magnetic resonance imaging (MRI) equipment. The radio-frequency-addressable sensor assemblies presented here comprise pairs of magnetic disks spaced by swellable hydrogel material; they reversibly reconfigure in rapid response to chosen stimuli, to give geometry-dependent, dynamic NMR spectral signatures. The sensors can be made from biocompatible materials, are themselves detectable down to low concentrations, and offer potential responsive NMR ...Continue Reading

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Citations

Oct 1, 2015·Scientific Reports·Francesca J NichollsMichel Modo
May 14, 2016·Nature Communications·Jae-Hyuck ChoiHong-Gyu Park
Aug 10, 2016·Nature Communications·J H HankiewiczR E Camley
Oct 21, 2016·Angewandte Chemie·Xiaopeng WangLiangti Qu
Jul 6, 2017·ACS Applied Materials & Interfaces·Zhao ZhengYiyun Cheng
Feb 28, 2018·Nature Materials·George J LuMikhail G Shapiro
Nov 27, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mladen BarbicAlan P Koretsky
Mar 13, 2019·Annual Review of Analytical Chemistry·Guoxin RongHeather A Clark
Jul 9, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mladen BarbicAlan P Koretsky
Apr 2, 2019·Nature Biomedical Engineering·Zhijie ZhuMichael C McAlpine
Apr 19, 2019·Nanomaterials·ChaeWon MunSung-Gyu Park
Jun 30, 2015·Nature Methods·Allison Doerr
Jan 22, 2020·Nature Communications·Peter A KorevaarJoanna Aizenberg
Aug 10, 2021·Frontiers in Robotics and AI·Lamar O MairDavid J Cappelleri

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Methods Mentioned

BETA
biosensing
chemical exchange saturation transfer
NMR

Software Mentioned

PARACEST

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