Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells

ACS Applied Materials & Interfaces
Zhimin ChangWen-Fei Dong

Abstract

Magnetic mesoporous silica nanoparticles (M-MSNs) are attractive candidates for the immunomagnetic isolation and detection of circulating tumor cells (CTCs). Understanding of the interactions between the effects of the shape of M-MSNs and CTCs is crucial to maximize the binding capacity and capture efficiency as well as to facilitate the sensitivity and efficiency of detection. In this work, fluorescent M-MSNs were rationally designed with sphere and rod morphologies while retaining their robust fluorescence and uniform surface functionality. After conjugation with the antibody of epithelial cell adhesion molecule (EpCAM), both of the differently shaped M-MSNs-EpCAM obtained achieved efficient enrichment of CTCs and fluorescent-based detection. Importantly, rodlike M-MSNs exhibited faster immunomagnetic isolation as well as better performance in the isolation and detection of CTCs in spiked cells and real clinical blood samples than those of their spherelike counterparts. Our results showed that shape engineering contributes positively toward immunomagnetic isolation, which might open new avenues to the rational design of magnetic-fluorescent nanoprobes for the sensitive and efficient isolation and detection of CTCs.

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Citations

Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Apr 24, 2020·Cancer Medicine·Laan Luo, Yongqing He
May 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhi-Min ChangZheng Wang
Sep 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hang ZhouPintong Huang
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jie LiChangfeng Fu
Jan 13, 2022·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Xuan HeChao Yang

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