Shape memory polymer foams for cerebral aneurysm reparation: effects of plasma sterilization on physical properties and cytocompatibility

Acta Biomaterialia
Luigi De NardoSilvia Farè

Abstract

Shape memory polyurethanes (SMPUs) represent promising candidate materials for aneurysm embolization, since they could enable clinical problems still associated with these clinical procedures to be overcome. In this work, we report on the characterization of physicochemical, thermomechanical and in vitro interface properties of two SMPU foams (Cold Hibernated Elastic Memory, CHEM), proposed as a material for embolization devices in minimally invasive procedures. Moreover, because device sterilization is mandatory for in vivo applications, effects on the properties of the foams after plasma sterilization were also evaluated. Both foams (CHEM 3520 and CHEM 5520) showed excellent shape recovery ability (recovery rate, R(r), up to 99%) in conventional shape recovery tests, performed at constant heating rate. Transition temperatures (T(trans)), determined by tandelta peaks in dynamic mechanical analysis (DMA), were 32.2 and 45.1 degrees C, for CHEM 3520 and 5520, respectively. The value of T(trans) affects shape memory ability in the recovery test at 37 degrees C, which simulates the behavior after implantation of the device: in fact, R(r) was significantly higher for lower T(trans) foam (R(r) approximately 82% and R(r) approximatel...Continue Reading

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Citations

Nov 22, 2011·Annals of Biomedical Engineering·Jennifer N RodriguezDuncan J Maitland
Apr 22, 2010·Journal of Materials Science. Materials in Medicine·Luigi De NardoSilvia Farè
Dec 12, 2012·ACS Applied Materials & Interfaces·Dawei ZhangMelissa A Grunlan
Apr 28, 2010·Expert Review of Medical Devices·Andreas LendleinChristian Wischke
Sep 8, 2012·Polymer·Dawei ZhangMelissa A Grunlan
Jun 13, 2013·Macromolecular Chemistry and Physics·Pooja SinghalThomas S Wilson
May 15, 2015·Journal of Biomedical Materials Research. Part a·Piotr RychterPiotr Dobrzynski
May 27, 2014·International Journal of Pharmaceutics·Ling-Ran DuTian-Yuan Fan
Apr 22, 2015·Journal of Materials Science. Materials in Medicine·Serena BertoldiMaria Cristina Tanzi
Apr 28, 2016·Advanced Materials·John G HardyManus J Biggs
May 20, 2016·Journal of Biomaterials Science. Polymer Edition·Rongrong LiuPing Zhang
May 7, 2013·Polymer Reviews·Keith HearonDuncan J Maitland
Sep 25, 2017·Advanced Healthcare Materials·Gregory I PetersonMatthew L Becker
Oct 17, 2017·Journal of Medical Devices·Rachael MuschalekDuncan J Maitland
Jan 25, 2011·Journal of Materials Chemistry·Ward SmallDuncan J Maitland
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Nov 19, 2011·The International Journal of Artificial Organs·Livia VisaiCarla Renata Arciola
Aug 30, 2016·Macromolecular Rapid Communications·Landon D NashDuncan J Maitland
Aug 28, 2020·APL Bioengineering·Alberto Di Bartolo, Ferry P W Melchels
Apr 5, 2014·Journal of Applied Biomaterials & Functional Materials·Paolo ArianoPaolo Fino
Sep 28, 2012·Journal of Applied Biomaterials & Functional Materials·Luigi De NardoSilvia Farè
Dec 18, 2012·Journal of Applied Biomaterials & Functional Materials·Shahriar SharifiDirk W Grijpma

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