Shape of population interfaces as an indicator of mutational instability in coexisting cell populations.

Physical Biology
Daniel Castillo, Maxim O Lavrentovich

Abstract

Cellular populations such as avascular tumors and microbial biofilms may 'invade' or grow into surrounding populations. The invading population is often comprised of a heterogeneous mixture of cells with varying growth rates. The population may also exhibit mutational instabilities, such as a heavy deleterious mutation load in a cancerous growth. We study the dynamics of a heterogeneous, mutating population competing with a surrounding homogeneous population, as one might find in a cancerous invasion of healthy tissue. We find that the shape of the population interface serves as an indicator for the evolutionary dynamics within the heterogeneous population. In particular, invasion front undulations become enhanced when the invading population is near a mutational meltdown transition or when the surrounding 'bystander' population is barely able to reinvade the mutating population. We characterize these interface undulations and the effective fitness of the heterogeneous population in one- and two-dimensional systems.

References

Mar 3, 1986·Physical Review Letters·M KardarY C Zhang
Jul 17, 1995·Physical Review Letters·J RiordanD ben-Avraham
Sep 16, 2000·Physical Review Letters·B Drossel, M Kardar
Jul 20, 2001·Physical Review Letters·I DornicH Hinrichsen
Dec 12, 2001·Physical Review Letters·E Moro
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GieseM Westphal
May 1, 1964·Mutation Research·H J MULLER
Oct 29, 2003·Biophysical Journal·Antonio BrúIsabel Brú
Apr 28, 2004·Biophysical Journal·Baochi NguyenMichael P Brenner
Feb 5, 2005·Breast Cancer Research and Treatment·Ruey-Feng ChangDar-Ren Chen
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Joao B Xavier, Kevin R Foster
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Oskar HallatschekDavid R Nelson
Aug 18, 2009·Evolution; International Journal of Organic Evolution·Oskar Hallatschek, David R Nelson
Oct 2, 2009·Physical Review Letters·Oskar Hallatschek, K S Korolev
Nov 26, 2009·Biochimica Et Biophysica Acta·Andriy Marusyk, Kornelia Polyak
Feb 24, 2010·Nature Reviews. Molecular Cell Biology·Simona NegriniThanos D Halazonetis
Apr 8, 2010·Biophysical Journal·Vincent TejedorRalf Metzler
May 24, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Clelia M Bordogna, Ezequiel V Albano
Oct 1, 2011·The American Naturalist·Kirill S KorolevKevin R Foster
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Jun 19, 2012·New Journal of Physics·Erik A MartensOskar Hallatschek
Aug 17, 2012·Nature·Florian L MullerRonald A DePinho
Oct 25, 2012·Insights Into Imaging·Fergus DavnallVicky Goh
Feb 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christopher D McFarlandLeonid A Mirny
Feb 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Maxim O LavrentovichDavid R Nelson
Sep 26, 2013·Radiology·Robert A GatenbyRobert J Gillies
Apr 18, 2014·Nature Reviews. Cancer·Kirill S KorolevJeff Gore
Apr 22, 2014·Physical Review Letters·Maxim O Lavrentovich, David R Nelson
May 24, 2014·Biophysical Journal·Clément VulinPascal Hersen
Aug 27, 2014·Physical Biology·Jakub Otwinowski, Joachim Krug
Oct 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christopher D McFarlandKirill S Korolev
Jan 28, 2015·Neoplasia : an International Journal for Oncology Research·Louis-Bastien WeiswaldVirginie Dangles-Marie
Feb 11, 2015·Nature Genetics·Andrea SottorivaChristina Curtis
Jan 1, 2014·Breast Cancer Research : BCR·Luciano G MartelottoJorge S Reis-Filho
Jun 21, 2016·Trends in Cell Biology·Marisa M MerinoEduardo Moreno
Jun 23, 2016·Biophysical Journal·Maxim O LavrentovichAndrew W Murray
Jul 28, 2016·Nature Reviews. Microbiology·Carey D NadellKevin R Foster
May 26, 2017·Cancer Research·Christopher D McFarlandLeonid A Mirny
Dec 1, 1993·Evolution; International Journal of Organic Evolution·W GabrielR Bürger
Aug 20, 2017·Genetics·Lars BosshardLaurent Excoffier
Dec 2, 2017·PLoS Computational Biology·Bryan T WeinsteinDavid R Nelson
Jan 19, 2018·Molecular Biology and Evolution·Yvonne WilliJosh Van Buskirk
Sep 29, 2018·PLoS Genetics·Kimberly J GilbertLaurent Excoffier
Dec 12, 2018·Bulletin of Mathematical Biology·Cindy Gidoin, Stephan Peischl
Jan 17, 2019·Molecular Biology and Evolution·Yuezheng ZhangXuemei Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Related Papers

The American Naturalist
Camille CoronAlexandre Robert
Evolution; International Journal of Organic Evolution
C ZeylJ A de Visser
The Journal of Heredity
Michael LynchWilfried Gabriel
BioRxiv : the Preprint Server for Biology
Yuezheng ZhangXuemei Lu
© 2021 Meta ULC. All rights reserved