Shape retaining injectable hydrogels for minimally invasive bulking

The Journal of Urology
Amanda J ThorntonDavid J Mooney

Abstract

Particle migration, poor shape definition and/or rapid resorption limit the success of current urethral bulking agents. We propose that shape defining porous scaffolds that allow cell infiltration and anchoring, and may be delivered in a minimally invasive manner may provide many advantageous features. Alginate hydrogels were prepared with varying degrees of covalent cross-linking and different pore characteristics. Dehydrated scaffolds were compressed into smaller, temporary forms, introduced into the dorsal subcutaneous space of CD-1 mice by minimally invasive delivery through a 10 gauge angiocatheter and rehydrated in situ with a saline solution delivered through the same catheter. Ionically cross-linked calcium alginate gel served as a control. Specimens were harvested at 2, 6, 12 and 24 weeks to evaluate implant shape retention and volume, cell infiltration and calcification, and the presence of an inflammatory response. A total of 90 scaffolds were implanted and 95% were recovered at the site of injection. All of these scaffolds successfully rehydrated and 80% recovered and maintained their original 3-dimensional shape for 6 months. Scaffold volume and tissue infiltration varied depending on the degree of alginate cross-l...Continue Reading

References

Aug 1, 1995·The Journal of Urology·M CendronG T Klauber
Apr 1, 1997·Biomaterials·L Shapiro, S Cohen
Jan 23, 1999·Biomaterials·J A RowleyD J Mooney
Sep 13, 2001·Journal of Biomedical Materials Research·A LoebsackC Halberstadt
Nov 17, 2001·Chemical Reviews·K Y Lee, D J Mooney
Jun 20, 2002·Current Opinion in Urology·Deborah J Lightner
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Eben AlsbergDavid J Mooney
Aug 19, 2003·Biomaterials·Jeanie L Drury, David J Mooney
Sep 5, 1993·Biotechnology and Bioengineering·A G MikosR Langer

❮ Previous
Next ❯

Citations

Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sidi A BencherifDavid J Mooney
Apr 23, 2008·Pediatric Research·Minal Patel, John P Fisher
Dec 18, 2013·Acta Biomaterialia·Sílvia J BidarraPedro L Granja
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xuanhe ZhaoDavid J Mooney
Aug 31, 2014·Advanced Drug Delivery Reviews·Conn L HastingsGarry P Duffy
Nov 28, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Lucy A BosworthSarah H Cartmell
Aug 14, 2012·Journal of Tissue Engineering and Regenerative Medicine·Fiona WegmanJacqueline Alblas
Mar 1, 2016·Journal of Biomaterials Science. Polymer Edition·Xiangdong BiQian Wang
Apr 7, 2010·Biomaterials·Christopher S D LeeZvi Schwartz
Jul 19, 2014·Acta Biomaterialia·Ortal Yom-TovHavazelet Bianco-Peled
Oct 21, 2017·Neurourology and Urodynamics·Julio T Chong, Vannita Simma-Chiang
Aug 2, 2006·Macromolecular Bioscience·Alexander D AugstDavid J Mooney
Apr 30, 2008·Journal of Biomedical Materials Research. Part a·Jeffrey P SpalazziHelen H Lu
Apr 27, 2005·The British Journal of Surgery·C J Vaizey, M A Kamm
Jun 3, 2020·Advanced Healthcare Materials·Maria Grazia RaucciLuigi Ambrosio
Apr 28, 2016·Advanced Materials·John G HardyManus J Biggs
Jan 1, 2015·Microarrays·Therese AndersenMichael Dornish
Dec 20, 2018·Bio-medical Materials and Engineering·Xiangdong BiAiye Liang
Oct 29, 2020·Tissue Engineering. Part a·Tengfei HeAmbika G Bajpayee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.