Shaping of the tumor microenvironment: Stromal cells and vessels

Seminars in Cancer Biology
Marzenna BlonskaFrancisco Vega

Abstract

Lymphomas develop and progress in a specialized tissue microenvironment such as bone marrow as well as secondary lymphoid organs such as lymph node and spleen. The lymphoma microenvironment is characterized by a heterogeneous population of stromal cells, including fibroblastic reticular cells, nurse-like cells, mesenchymal stem cells, follicular dendritic cells, and inflammatory cells such as macrophages, T- and B-cells. These cell populations interact with the lymphoma cells to promote lymphoma growth, survival and drug resistance through multiple mechanisms. Angiogenesis is also recognized as an important factor associated with lymphoma progression. In recent years, we have learned that the interaction between the malignant and non-malignant cells is bidirectional and resembles, at least in part, the pattern seen between non-neoplastic lymphoid cells and the normal microenvironment of lymphoid organs. A summary of the current knowledge of lymphoma microenvironment focusing on the cellular components will be reviewed here.

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Citations

Aug 30, 2016·Current Opinion in Chemical Engineering·Esak LeeChristopher S Chen
Jan 6, 2016·Proceedings of the National Academy of Sciences of the United States of America·Marina WeissmannNeta Ilan
Jun 1, 2015·Seminars in Cancer Biology·Antonino Carbone, Anas Younes
Aug 15, 2015·Stem Cells International·Pascal David Johann, Ingo Müller
Apr 7, 2017·Journal of the National Cancer Institute·Stefan B EichmüllerBarbara Seliger
Jan 15, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Lei ShenJi-Cheng Liu
Apr 1, 2019·Molecular Cancer·Jana PlavaSvetlana Miklikova
Nov 20, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J RuanD Zhou
Nov 7, 2019·Cancer Research·Udayan BhattacharyaIsrael Vlodavsky
Apr 13, 2021·Frontiers in Oncology·Benedetta ApollonioAlan G Ramsay
May 12, 2021·Experimental Hematology & Oncology·Linbang WangZhengxue Quan
Mar 24, 2021·Annual Review of Biomedical Engineering·Venktesh S ShirureSteven C George

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