Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis

Biomolecules
Michael PrattesRobin E Stanley

Abstract

AAA-ATPases are molecular engines evolutionarily optimized for the remodeling of proteins and macromolecular assemblies. Three AAA-ATPases are currently known to be involved in the remodeling of the eukaryotic ribosome, a megadalton range ribonucleoprotein complex responsible for the translation of mRNAs into proteins. The correct assembly of the ribosome is performed by a plethora of additional and transiently acting pre-ribosome maturation factors that act in a timely and spatially orchestrated manner. Minimal disorder of the assembly cascade prohibits the formation of functional ribosomes and results in defects in proliferation and growth. Rix7, Rea1, and Drg1, which are well conserved across eukaryotes, are involved in different maturation steps of pre-60S ribosomal particles. These AAA-ATPases provide energy for the efficient removal of specific assembly factors from pre-60S particles after they have fulfilled their function in the maturation cascade. Recent structural and functional insights have provided the first glimpse into the molecular mechanism of target recognition and remodeling by Rix7, Rea1, and Drg1. Here we summarize current knowledge on the AAA-ATPases involved in eukaryotic ribosome biogenesis. We highlight...Continue Reading

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Citations

Apr 25, 2020·The Journal of Cell Biology·Dan Li, Jianlong Wang
Sep 17, 2020·Cells·Emilien OrgebinMarc Baud'huin
Apr 29, 2020·International Journal of Molecular Sciences·Lisa KoflerHelmut Bergler
Oct 26, 2020·Current Opinion in Structural Biology·Meredith N FrazierRobin E Stanley
Mar 16, 2021·Nucleic Acids Research·Gerald Ryan R AquinoMarkus T Bohnsack
Jun 11, 2021·Nature Communications·Michael PrattesHelmut Bergler
Oct 12, 2021·Critical Reviews in Biochemistry and Molecular Biology·Yousuf A KhanAxel T Brunger

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Methods Mentioned

BETA
co-immunoprecipitation
NMR
GTPase

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