Shared and disorder-specific task-positive and default mode network dysfunctions during sustained attention in paediatric Attention-Deficit/Hyperactivity Disorder and obsessive/compulsive disorder

NeuroImage. Clinical
L NormanKatya Rubia

Abstract

Patients with Attention-Deficit/Hyperactivity Disorder (ADHD) and obsessive/compulsive disorder (OCD) share problems with sustained attention, and are proposed to share deficits in switching between default mode and task positive networks. The aim of this study was to investigate shared and disorder-specific brain activation abnormalities during sustained attention in the two disorders. Twenty boys with ADHD, 20 boys with OCD and 20 age-matched healthy controls aged between 12 and 18 years completed a functional magnetic resonance imaging (fMRI) version of a parametrically modulated sustained attention task with a progressively increasing sustained attention load. Performance and brain activation were compared between groups. Only ADHD patients were impaired in performance. Group by sustained attention load interaction effects showed that OCD patients had disorder-specific middle anterior cingulate underactivation relative to controls and ADHD patients, while ADHD patients showed disorder-specific underactivation in left dorsolateral prefrontal cortex/dorsal inferior frontal gyrus (IFG). ADHD and OCD patients shared left insula/ventral IFG underactivation and increased activation in posterior default mode network relative to co...Continue Reading

Citations

Jul 27, 2018·Journal of Attention Disorders·Shereen ElmaghrabiFrancisco X Castellanos
Mar 20, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Loes J Koorenhof, Eleanor J Dommett
Jun 21, 2019·Brain Imaging and Behavior·Virginia de Oliveira RosaLuis Augusto Paim Rohde
Sep 21, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Maria SuñolCarles Soriano-Mas
Jul 31, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Olivia S KowalczykKatya Rubia
Dec 12, 2020·Frontiers in Human Neuroscience·Gennady G KnyazevPavel D Rudych
Nov 25, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Nicole R KarcherDeanna M Barch
Dec 7, 2021·Frontiers in Systems Neuroscience·Katherine G WarthenBrian J Mickey

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