Shared and distinct gray matter abnormalities in schizophrenia, schizophrenia relatives and bipolar disorder in association with cognitive impairment

Schizophrenia Research
Christian KnöchelViola Oertel-Knöchel

Abstract

Cognitive impairments have been linked to structural and functional alterations in frontal and subcortical brain regions, ultimately leading to fronto-thalamic connectivity disturbances. We hypothesized that such neuronal disruptions in frontal and subcortical structures may account for neuropsychological deficits in schizophrenia (SZ), schizophrenia relatives and bipolar disorder (BD). We acquired T1-weighted anatomical MRI sequences in 209 participants: 57 SZ patients, 47 first-degree relatives of SZ patients, 48 BD I patients and 57 healthy controls. We computed group comparisons of gray matter (GM) volume in frontal and basal ganglia regions-of-interest, followed by correlation analysis between psychomotor speed, executive functioning and learning and GM volumes in candidate regions. Several frontal GM volume reductions as well as GM increases in the thalamus and the putamen were exhibited in SZ patients as compared to controls. The same finding was observed - less pronounced - when comparing SZ relatives and controls. BD patients presented GM volume increases in the basal ganglia in comparison to controls. In SZ patients, increases in bilateral thalamus GM volume and decreases in left middle and superior frontal gyrus volu...Continue Reading

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Citations

Apr 24, 2019·The European Journal of Neuroscience·Laura EgloffAnita Riecher-Rössler
Mar 7, 2021·Brain Sciences·Gianluca SerafiniDisease Management Team On Dementia Of The Irccs Ospedale Policlinico San Martino
Apr 2, 2021·Frontiers in Genetics·Evan R HermannWinyoo Chowanadisai
Jun 8, 2021·Schizophrenia Bulletin·James A KarantonisTamsyn E Van Rheenen

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