Shared and specific dynamics of brain segregation and integration in bipolar disorder and major depressive disorder: A resting-state functional magnetic resonance imaging study.

Journal of Affective Disorders
Zhenye LuoYing Wang

Abstract

When bipolar disorder (BD) presents as the depressive state, it is often misdiagnosed as major depressive disorder (MDD). However, few studies have focused on dynamic differences in local brain activity and connectivity between BD and MDD. Therefore, the present study explored shared and specific patterns of abnormal dynamic brain segregation and integration in BD and MDD patients. BD Patients (n = 106), MDD patients (n = 114), and 130 healthy controls (HCs) underwent resting state functional magnetic resonance imaging (fMRI). We first used a sliding window analysis to evaluate the dynamic amplitude of low-frequency fluctuations (dALFF) and, based on the altered dALFF, further analyzed the dynamic functional connectivity (dFC) using a seed-based approach. Both the BD and MDD groups showed decreased temporal variability of the dALFF (less dynamic segregation) in the bilateral posterior cingulate cortex (PCC)/precuneus compared with the HCs. The MDD group showed increased temporal variability of the dALFF (more dynamic segregation) in the left putamen compared with the controls, but there was no significant difference between the BD and HCs. The dFC analysis also showed that both the BD and MDD groups had reduced dFC (less dynami...Continue Reading

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