Abstract
Cancers are often associated with mutations in multiple genes; thus, studying the distributions of genes that harbor cancer-promoting mutations in cancer samples and their co-occurrences could provide insights into cancer diagnostics and treatment. Using data from the Catalogue of Somatic Mutations in Cancer (COSMIC), we found that mutated genes in cancer samples followed a power-law distribution. For instance, a few genes were mutated in a large number of samples (designated as high-frequent genes), while a large number of genes were only mutated in a few samples. This power-law distribution can be found in samples of all cancer types as well as individual cancers. In samples where two or more mutated genes are found, the high-frequent genes, i.e., those that were frequently mutated, often did not co-occur with other genes, while the other genes often tended to co-occur. Co-occurrences of mutated genes were often unique to a certain cancer; however, some co-occurrences were shared by multiple cancer types. Our results revealed distinct patterns of high-frequent genes and those that were less-frequently mutated in the cancer samples in co-occurring and anti-co-occurring networks. Our results indicated that distinct treatment st...Continue Reading
References
Nov 19, 2004·Nature·Michael B Kastan, Jiri Bartek
Jun 14, 2005·Genomics·Xijin GeHiroyuki Aburatani
Nov 7, 2009·Science·Nathalie CartierPatrick Aubourg
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alan F Rubin, Phil Green
Feb 25, 2010·Bioinformatics·Guangchuang YuShengqi Wang
Jul 27, 2010·Bioinformatics·Christian T LopesGary D Bader
Oct 20, 2010·PloS One·Qinghua Cui
Jan 11, 2011·International Immunopharmacology·Qi NiuWenhua Zhu
Feb 19, 2011·Nature Reviews. Genetics·Michael J DixonJeffrey C Murray
Aug 2, 2011·Nature Genetics·Laura PasqualucciRiccardo Dalla-Favera
Feb 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jens G LohrTodd R Golub
May 9, 2012·Nature Genetics·Cécile GuichardJessica Zucman-Rossi
May 17, 2012·Cancer Discovery·Ethan CeramiNikolaus Schultz
May 23, 2012·Cell·Serena Nik-ZainalUNKNOWN Breast Cancer Working Group of the International Cancer Genome Consortium
Jan 16, 2013·Chemotherapy Research and Practice·Zahi MitriRuth O'Regan
Apr 27, 2013·Bioinformatics·Hashem A ShihabTom R Gaunt
May 23, 2013·PLoS Computational Biology·Wei-Hua ChenPeer Bork
Dec 29, 2013·Nucleic Acids Research·Parimal KumarTatyana V Pestova
Feb 21, 2014·BMC Medical Genomics·Peilin JiaZhongming Zhao
Mar 25, 2014·Current Opinion in Genetics & Development·Ludmil B Alexandrov, Michael R Stratton