PMID: 2511168Oct 1, 1989Paper

Shared class II MHC polymorphisms between humans and chimpanzees

Human Immunology
W M FanJ Klein

Abstract

To gain an insight into the evolution of the major histocompatibility complex alleles, three DRB and one DRA genes were isolated from chimpanzee cDNA libraries. The nucleotide sequences of the chimpanzee DRB (ChLA-DRB) genes were then compared with those of the available HLA-DRB alleles by constructing unrooted phylogenetic trees. All three ChLA-DRB genes were found to be more closely related to certain HLA-DRB alleles than unrelated HLA-DRB alleles are to each other. Since available evidence does not support the convergent evolution of MHC alleles, this result is consistent with the idea that closely related ChLA-DRB and HLA-DRB alleles are derived from common ancestral alleles, the existence of which predates the divergence of human and chimpanzee lineages. The predicted amino acid sequences of mature ChLA-DRA and HLA-DRA molecules differ by only one amino acid.

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Citations

Jul 1, 1992·Journal of Molecular Evolution·E P LeeflangC W Schmid
Jan 1, 1995·Immunogenetics·T L GarberD I Watkins
Jan 1, 1992·Immunogenetics·V VincekJ Klein
Jan 1, 1995·Immunogenetics·B L SlierendregtR E Bontrop
Jan 1, 1992·Immunogenetics·N Takahata, Y Satta
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C SchönbachJ Klein
Jan 1, 1990·Immunogenetics·U M Sarmiento, R Storb
Jan 1, 1989·Immunogenetics·M KasaharaJ Klein
Jan 1, 1996·Immunogenetics·R GraserJ Klein
Jan 1, 1990·Immunologic Research·U B Gyllensten, H A Erlich
Jun 27, 2007·Journal of Molecular Evolution·Andres Aguilar, John Carlos Garza
May 1, 1991·Human Immunology·J KleinC Schönbach
Jan 1, 1993·Human Immunology·U B Gyllensten, H A Erlich
Jun 1, 1993·Human Immunology·B GrahovacJ Klein
Feb 1, 1995·Human Immunology·N Otting, R E Bontrop
Sep 1, 1994·Human Immunology·A CorellA Arnaiz-Villena
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·U B Gyllensten, H A Erlich
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K GustafssonD H Sachs
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A S Lundberg, H O McDevitt
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y SattaJ Klein
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·S N McAdamD I Watkins
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·F J AyalaJ Klein
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·L K Gaur, G T Nepom
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·C Su, M Nei
Sep 6, 2005·Genome Research·Christopher K RaymondMaynard V Olson
Aug 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·L F Cadavid, D I Watkins
Feb 1, 1990·Immunological Reviews·J Klein, N Takahata
Feb 1, 1990·Immunological Reviews·F FigueroaJ Klein
Feb 1, 1990·Immunological Reviews·M KasaharaJ Gutknecht
Feb 1, 1995·Immunological Reviews·C Wills, D R Green

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