Shared genetic and environmental influences on early temperament and preschool psychiatric disorders in Hispanic twins

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Judy L SilbergGlorisa Canino

Abstract

Despite an increasing recognition that psychiatric disorders can be diagnosed as early as preschool, little is known how early genetic and environmental risk factors contribute to the development of psychiatric disorders during this very early period of development. We assessed infant temperament at age 1, and attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and separation anxiety disorder (SAD) at ages 3 through 5 years in a sample of Hispanic twins. Genetic, shared, and non-shared environmental effects were estimated for each temperamental construct and psychiatric disorder using the statistical program MX. Multivariate genetic models were fitted to determine whether the same or different sets of genes and environments account for the co-occurrence between early temperament and preschool psychiatric disorders. Additive genetic factors accounted for 61% of the variance in ADHD, 21% in ODD, and 28% in SAD. Shared environmental factors accounted for 34% of the variance in ODD and 15% of SAD. The genetic influence on difficult temperament was significantly associated with preschool ADHD, SAD, and ODD. The association between ODD and SAD was due to both genetic and family environmental factors....Continue Reading

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Citations

Apr 27, 2016·Expert Opinion on Pharmacotherapy·Ann C Childress
Dec 22, 2020·Journal of Developmental and Behavioral Pediatrics : JDBP·Derek SoledAndrew Adesman
Apr 18, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Elizabeth ShephardGuilherme V Polanczyk

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