Shared genetic basis for obstructive sleep apnea and adiposity measures.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Sanjay R PatelSusan Redline

Abstract

Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified. A total of 1802 individuals from 310 families in the Cleveland Family Study underwent home sleep studies as well as standardized assessment of body mass index (BMI) and circumferences at the waist, hip and neck. In 713 participants with laboratory sleep studies, fasting blood samples were assayed for leptin, adiponectin and resistin. Variance component models were used to estimate heritability and genetic correlations. The heritability of the apnea hypopnea index (AHI) was 0.37+/-0.04 and 0.33+/-0.07 for home and laboratory sleep studies, respectively. The genetic correlations between AHI and anthropomorphic adiposity measures ranged from 0.57 to 0.61, suggesting that obesity can explain nearly 40% of the genetic variance in sleep apnea. The magnitude of the genetic correlations between apnea severity and adipokine levels was substantially less than those with anthropomorphic measures, ranging from 0.11 to 0.46. After adjusting for BMI, no significant genetic correlation with apnea severity was observed for any...Continue Reading

References

May 24, 1990·The New England Journal of Medicine·A J StunkardG E McClearn
Jul 4, 1986·JAMA : the Journal of the American Medical Association·A J StunkardZ Hrubec
Feb 1, 1995·Annals of Internal Medicine·R Mathur, N J Douglas
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·S RedlineP Krejci
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·G Pillar, P Lavie
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·C P O'donnellP L Smith
Dec 21, 2000·JAMA : the Journal of the American Medical Association·P E PeppardJ Skatrud
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·A G ComuzzieA Kissebah
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Terry YoungDaniel J Gottlieb
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Thorarinn GislasonKari Stefansson
Dec 31, 2002·American Journal of Human Genetics·Lyle J PalmerSusan Redline
Apr 9, 2004·American Journal of Respiratory and Critical Care Medicine·Lyle J PalmerSusan Redline
Sep 15, 2005·Journal of Applied Physiology·Sanjay R Patel
May 4, 2006·The Journal of Clinical Endocrinology and Metabolism·Claudia MenzaghiVincenzo Trischitta
Sep 12, 2006·Proceedings of the American Thoracic Society·Irene Lang, Kim Kerr

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Citations

Jun 19, 2015·Chest·Lilian K G de PaulaGeraldo Lorenzi-Filho
Oct 27, 2012·Neurologic Clinics·Octavian C Ioachimescu, Nancy A Collop
Mar 28, 2012·Biochimie·Jana BreitfeldPeter Kovacs
Mar 6, 2012·European Journal of Internal Medicine·Morohunfolu E AkinnusiAli A El-Solh
Dec 28, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y SongJ Y Lee
Dec 27, 2008·Progress in Cardiovascular Diseases·Nabil M Al LawatiNajib T Ayas
May 29, 2016·Sleep Medicine Clinics·Rohit BudhirajaSusan Redline
Nov 26, 2015·The Psychiatric Clinics of North America·John Khoury, Karl Doghramji
Jun 19, 2013·Journal of the American College of Cardiology·Luciano F DragerGeraldo Lorenzi-Filho
Mar 16, 2016·American Journal of Respiratory and Critical Care Medicine·Brian E CadeSusan Redline
Oct 12, 2016·Journal of Clinical Laboratory Analysis·Yanli LiShaoxi Cai
Nov 8, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sutapa MukherjeeLyle J Palmer
Aug 16, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Vitish SinglaSamagra Agarwal
Sep 25, 2008·Current Opinion in Pulmonary Medicine·Daniel J Gottlieb
Mar 24, 2009·Journal of Cardiopulmonary Rehabilitation and Prevention·Joshua B WennerNajib T Ayas
Jan 1, 2017·Expert Review of Precision Medicine and Drug Development·Manuel Sânchez-de-la-Torre, David Gozal
Feb 7, 2020·Psychological Medicine·Juan J Madrid-ValeroAlice M Gregory
Nov 20, 2019·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Chun Ting AuAlbert M Li
Apr 21, 2010·Experimental Biology and Medicine·Camila GuindaliniSergio Tufik
Dec 20, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Yuvreet KaurDavid Meyre
Apr 13, 2018·Deutsches Ärzteblatt International·Vasiliki KoretsiSpyridon N Papageorgiou
Apr 9, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael ElgartTamar Sofer
May 8, 2021·The European Respiratory Journal·Heming WangSusan Redline
Feb 26, 2020·Archivos de bronconeumología·Daniel Morell-GarciaAntonia Barceló
Jun 6, 2021·Archivos de bronconeumología·Daniel Morell-GarciaAntonia Barceló
Aug 28, 2021·Genome Medicine·Brian E CadeUNKNOWN TOPMed Sleep Working Group
May 7, 2009·Current Opinion in Anaesthesiology

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