Shared genetic variance between obesity and white matter integrity in Mexican Americans

Frontiers in Genetics
Elena A SpiekerJoanne E Curran

Abstract

Obesity is a chronic metabolic disorder that may also lead to reduced white matter integrity, potentially due to shared genetic risk factors. Genetic correlation analyses were conducted in a large cohort of Mexican American families in San Antonio (N = 761, 58% females, ages 18-81 years; 41.3 ± 14.5) from the Genetics of Brain Structure and Function Study. Shared genetic variance was calculated between measures of adiposity [(body mass index (BMI; kg/m(2)) and waist circumference (WC; in)] and whole-brain and regional measurements of cerebral white matter integrity (fractional anisotropy). Whole-brain average and regional fractional anisotropy values for 10 major white matter tracts were calculated from high angular resolution diffusion tensor imaging data (DTI; 1.7 × 1.7 × 3 mm; 55 directions). Additive genetic factors explained intersubject variance in BMI (heritability, h (2) = 0.58), WC (h (2) = 0.57), and FA (h (2) = 0.49). FA shared significant portions of genetic variance with BMI in the genu (ρG = -0.25), body (ρG = -0.30), and splenium (ρG = -0.26) of the corpus callosum, internal capsule (ρG = -0.29), and thalamic radiation (ρG = -0.31) (all p's = 0.043). The strongest evidence of shared variance was between BMI/WC an...Continue Reading

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Citations

Nov 30, 2018·Human Brain Mapping·Peter KochunovThomas E Nichols
May 12, 2018·Annals of the New York Academy of Sciences·Alexis PorterTimothy Verstynen
Aug 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Uku VainikAlain Dagher
Aug 24, 2017·Obesity·Meghann RyanL Elliot Hong
May 23, 2020·Neuroscience and Biobehavioral Reviews·Laura W M VergoossenMiranda T Schram
Oct 27, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Frauke BeyerA Veronica Witte
Sep 19, 2017·Metabolism: Clinical and Experimental·Freddy J AlfaroVera Novak

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
SOLAR
FSL

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