PMID: 11903535Mar 21, 2002Paper

Shared mechanisms and comorbidities in neurologic and psychiatric disorders

Headache
S D Silberstein

Abstract

Migraine may be comorbid with several other neurologic and psychiatric conditions, including mood disorders (eg, depression, anxiety, panic disorder), epilepsy, stroke, and essential tremor. Comorbidity presents physicians with opportunities and challenges for both diagnosis and treatment. All diseases must be considered, and therapeutic strategies may need to be modified to avoid potential drug interactions. Comorbidities also may provide clues to the pathophysiologies and any shared mechanisms of the two disorders. Longitudinal studies have demonstrated a bidirectional influence between migraine and major depression, but not between migraine and other severe headache. Migraine is strongly and consistently associated with panic disorder. The risk of migraine in epilepsy is increased particularly in individuals with head trauma, partial seizures, and a positive family history of migraine. The influence is bidirectional. There is also growing evidence of an association between migraine and stroke, particularly among women of childbearing age and individuals who experience migraine with aura. Lastly, a bidirectional association between migraine and essential tremor also exists. These findings suggest that migraine, major depressi...Continue Reading

References

Feb 17, 1975·JAMA : the Journal of the American Medical Association
Dec 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·N BiaryP Langenberg
Sep 1, 1990·Archives of General Psychiatry·K R MerikangasH Isler
Jan 1, 1989·Journal of Clinical Epidemiology·J B Henrich, R I Horwitz
Nov 1, 1985·Archives of Neurology·N Biary, W Koller
Feb 1, 1995·Archives of Neurology·J E BuringC Hennekens
Nov 1, 1994·Neurology·R Ottman, R B Lipton
Dec 1, 1993·Neurology·D A Marks, B L Ehrenberg
Jul 31, 1993·BMJ : British Medical Journal·C TzourioM G Bousser
Dec 1, 1995·Biological Psychiatry·K R MerikangasM Sandler
Jun 28, 2000·Current Opinion in Neurology·S D Silberstein, R B Lipton
Dec 1, 1970·Journal of Chronic Diseases·A R Feinstein

❮ Previous
Next ❯

Citations

Feb 18, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Carmen V Molgat, Scott B Patten
Jun 1, 2010·Cephalalgia : an International Journal of Headache·Piero BarbantiAlfredo Berardelli
Jul 24, 2014·CNS Oncology·Florien W BoeleJan J Heimans
Nov 5, 2002·Current Pain and Headache Reports·Vincenzo Guidetti, Federica Galli
Sep 2, 2006·Current Pain and Headache Reports·Jack Gladstein
Dec 31, 2004·Current Pain and Headache Reports·Roger CadyCurtis Schreiber
Jul 2, 2004·Nature Medicine·Michael A Rogawski, Wolfgang Löscher
Jul 30, 2010·European Journal of Clinical Pharmacology·Mohamad KarouniCecilie Johannessen Landmark
Jun 1, 2005·Headache·Donald B PenzienUNKNOWN American Headache Society Behavioral Clinical Trials Workgroup
Nov 23, 2011·Headache·Chaichana NimnuanAnan Srikiatkhachorn
Jan 19, 2007·Psychotherapy and Psychosomatics·Giovanni Abbate-DagaLorenzo Pinessi
Jan 27, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Wing S WongRichard Fielding
Apr 9, 2009·The Journal of Headache and Pain·Federica GalliVincenzo Guidetti
Jun 1, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F d'OnofrioD Cologno
Dec 4, 2012·Cephalalgia : an International Journal of Headache·Umberto BalottinFederica Galli
Jun 20, 2020·Journal of Affective Disorders·Dong Hyun LeeMin Kyung Chu
Aug 8, 2006·Regulatory Peptides·Mariano Ruiz-GayoSoledad Fernández-Alfonso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.