Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren's Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study

Journal of Immunology Research
Hadas Ben-EliAbraham Solomon

Abstract

To assess whether there are shared exposures associated with Sjogren's syndrome (SS), dry eye syndrome (DES), and B-cell non-Hodgkin lymphoma (B-NHL), in order to determine whether they are etiologically related. In a clinic-based case-control study, 702 participants (91 SS, 120 DES, 211 (age and sex frequency-matched) controls, and 280 B-NHL cases) were recruited and interviewed regarding exposures, medical history, and family history. Female predominance was noted in SS (ratio 9.2 : 1). Eye dryness was severest in SS compared to DES and controls (P < 0.001). Compared to controls, alcohol consumption was inversely associated with NHL, DES, and SS (odds ratio (OR) = 0.47, 95% confidence interval (CI): 0.31-0.71; OR = 0.54, 95% CI: 0.33-0.88; and OR = 0.26, 95% CI: 0.14-0.49, respectively), while a previous history of infection requiring hospitalization was positively associated with all three conditions: NHL (OR = 1.92; 95% CI: 1.23-2.99), DES (OR = 3.29; 95% CI: 1.97-5.47), and SS (OR = 4.74; 95% CI: 2.66-8.44). NHL patients were more likely to report first-degree relatives with hematologic cancer, while having first-degree relatives with an autoimmune disease (AID) was associated with SS (OR = 5.25; 95% CI: 2.59-10.63) and DE...Continue Reading

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Citations

Feb 29, 2020·Journal of Internal Medicine·A BjörkM Wahren-Herlenius
Mar 1, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Dimitra MakryniotiGeorge Lagoumintzis
Nov 1, 2021·Rheumatology·Valeria ValimGabriela Hernández-Molina
Dec 5, 2020·Panminerva Medica·Alessia AlunnoFrancesco Carubbi

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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