Shared polygenic risk for ADHD, executive dysfunction and other psychiatric disorders.

Translational Psychiatry
Suhua ChangStephen V Faraone

Abstract

Many psychiatric disorders are associated with impaired executive functioning (EF). The associated EF component varies by psychiatric disorders, and this variation might be due to genetic liability. We explored the genetic association between five psychiatric disorders and EF in clinically-recruited attention deficit hyperactivity disorder (ADHD) children using polygenic risk score (PRS) methodology. Genome-wide association study (GWAS) summary data for ADHD, major depressive disorder (MDD), schizophrenia (SZ), bipolar disorder (BIP) and autism were used to calculate the PRSs. EF was evaluated by the Stroop test for inhibitory control, the trail-making test for cognitive flexibility, and the digital span test for working memory in a Chinese ADHD cohort (n = 1147). Exploratory factor analysis of the three measures identified one principal component for EF (EF-PC). Linear regression models were used to analyze the association between each PRS and the EF measures. The role of EF measures in mediating the effects of the PRSs on ADHD symptoms was also analyzed. The result showed the PRSs for MDD, ADHD and BIP were all significantly associated with the EF-PC. For each EF component, the association results were different for the PRSs ...Continue Reading

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Citations

Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Jutta S MayerChristine M Freitag
Apr 6, 2021·Psychological Medicine·Isabell BrikellJoanna Martin
May 28, 2021·Autism Research : Official Journal of the International Society for Autism Research·David MasonFrancesca Happé
Jun 2, 2021·Current Opinion in Genetics & Development·Jennifer Gladys MulleJens Hjerling-Leffler
May 2, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Wonuola A AkingbuwaChristel M Middeldorp
Jul 28, 2021·Human Molecular Genetics·Katherine W Eyring, Daniel H Geschwind

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Methods Mentioned

BETA
PCA

Software Mentioned

R package “ mediation
R
SPSS
IMPUTE2
SHAPEIT
EIGENSOFT

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