Sharing Structure and Function in Biological Design with SBOL 2.0

ACS Synthetic Biology
Nicholas RoehnerChris J Myers

Abstract

The Synthetic Biology Open Language (SBOL) is a standard that enables collaborative engineering of biological systems across different institutions and tools. SBOL is developed through careful consideration of recent synthetic biology trends, real use cases, and consensus among leading researchers in the field and members of commercial biotechnology enterprises. We demonstrate and discuss how a set of SBOL-enabled software tools can form an integrated, cross-organizational workflow to recapitulate the design of one of the largest published genetic circuits to date, a 4-input AND sensor. This design encompasses the structural components of the system, such as its DNA, RNA, small molecules, and proteins, as well as the interactions between these components that determine the system's behavior/function. The demonstrated workflow and resulting circuit design illustrate the utility of SBOL 2.0 in automating the exchange of structural and functional specifications for genetic parts, devices, and the biological systems in which they operate.

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Citations

Oct 22, 2016·ACS Synthetic Biology·Angel Goñi-MorenoVíctor de Lorenzo
Dec 23, 2016·Nucleic Acids Research·Lauren B A WoodruffChristopher A Voigt
Dec 31, 2016·ACS Synthetic Biology·James Scott-Brown, Antonis Papachristodoulou
Jan 13, 2017·ACS Synthetic Biology·Hiroyuki KuwaharaXin Gao
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Oct 18, 2016·ACS Synthetic Biology·Bryan S DerThomas E Gorochowski
Apr 26, 2017·ACS Synthetic Biology·Michael ZhangChris J Myers
Jun 22, 2018·PloS One·Jacob BealUNKNOWN with the iGEM Interlab Study Contributors
Jun 18, 2017·Biochemical Society Transactions·Chris J MyersZach Zundel
May 31, 2017·Frontiers in Plant Science·Amy Marshall-ColonXin-Guang Zhu
Feb 6, 2020·Nature Communications·Bryan A BartleyElizabeth A Strychalski
Oct 6, 2020·Frontiers in Bioengineering and Biotechnology·James Alastair McLaughlinChris J Myers
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Mar 27, 2020·Frontiers in Plant Science·Félix de CarpentierAntoine Danon
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Jun 22, 2021·ACS Synthetic Biology·Logan TerryChris J Myers
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Jul 30, 2021·ACS Synthetic Biology·Benjamin HatchChris J Myers
Dec 31, 2016·ACS Synthetic Biology·Zach ZundelChris J Myers
Aug 14, 2020·ACS Synthetic Biology·Pedro FontanarrosaChris Myers
Aug 14, 2020·ACS Synthetic Biology·Bradley BrownAnil Wipat
Apr 26, 2017·ACS Synthetic Biology·Martín GutiérrezAlfonso Rodríguez-Patón
Jan 11, 2018·ACS Synthetic Biology·James Alastair McLaughlinAnil Wipat
Dec 23, 2016·ACS Synthetic Biology·Ernst OberortnerSamuel Deutsch
Jun 27, 2020·ACS Synthetic Biology·Matthew R Lakin, Andrew Phillips
Jun 27, 2018·ACS Synthetic Biology·Leandro WatanabeChris Myers
Jul 2, 2019·ACS Synthetic Biology·Nicholas RoehnerChris J Myers
May 1, 2019·ACS Synthetic Biology·Jing Wui YeohChueh Loo Poh
Apr 11, 2020·ACS Synthetic Biology·Jeanet ManteChris Myers
May 22, 2018·ACS Synthetic Biology·Göksel MisirliAnil Wipat
Oct 5, 2021·ACS Synthetic Biology·Lukas BuecherlChris J Myers
May 10, 2017·New Biotechnology·Víctor de Lorenzo, Markus Schmidt

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