The Synthetic Biology Open Language (SBOL) is a standard that enables collaborative engineering of biological systems across different institutions and tools. SBOL is developed through careful consideration of recent synthetic biology trends, real use cases, and consensus among leading researchers in the field and members of commercial biotechnology enterprises. We demonstrate and discuss how a set of SBOL-enabled software tools can form an integrated, cross-organizational workflow to recapitulate the design of one of the largest published genetic circuits to date, a 4-input AND sensor. This design encompasses the structural components of the system, such as its DNA, RNA, small molecules, and proteins, as well as the interactions between these components that determine the system's behavior/function. The demonstrated workflow and resulting circuit design illustrate the utility of SBOL 2.0 in automating the exchange of structural and functional specifications for genetic parts, devices, and the biological systems in which they operate.
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
Eugene--a domain specific language for specifying and constraining synthetic biological parts, devices, and systems.
Automatic compilation from high-level biologically-oriented programming language to genetic regulatory networks.
Contextualizing context for synthetic biology--identifying causes of failure of synthetic biological systems.
Design, implementation and practice of JBEI-ICE: an open source biological part registry platform and tools.
Characterization of 582 natural and synthetic terminators and quantification of their design constraints
A methodology to annotate systems biology markup language models with the synthetic biology open language
The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology
Synthetic biology of multicellular systems: new platforms and applications for animal cells and organisms
Improving Synthetic Biology Communication: Recommended Practices for Visual Depiction and Digital Submission of Genetic Designs
BioMaster: An Integrated Database and Analytic Platform to Provide Comprehensive Information About BioBrick Parts.
Comparative analysis of three studies measuring fluorescence from engineered bacterial genetic constructs.
Birth of a Photosynthetic Chassis: A MoClo Toolkit Enabling Synthetic Biology in the Microalga Chlamydomonas reinhardtii
Bioinformatics in Biomedicine
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