Shear-aggregated fibronectin with anti-adhesive properties

Journal of Tissue Engineering and Regenerative Medicine
Olivier A BranfordV Mudera

Abstract

Biomaterials based on proteins, such as fibronectin, have the potential to guide cell and tissue behaviour during healing as a function of their unique mechanical and bioactive properties. Fibronectin has been reported as a scaffold for attachment of fibroblasts and subsequent deposition of collagen. We have recently developed a derivative process of shear-aggregated fibronectin that prevents cell attachment without causing cell death. This has potential applications in clinical situations where adhesions form across gliding surfaces and cause loss of function, e.g. peritoneal or flexor tendon adhesions. This in vitro study tested this derivative fibronectin biomaterial and its effects on aggressive adhesion-forming cells, using rabbit flexor tendon synovial fibroblasts. We investigated degradation of the novel biomaterial, and attachment of fibroblasts to glass coated with the biomaterial, relative to fibroblast attachment to uncoated and fibronectin-coated glass. We assessed infiltration of the derivative fibronectin biomaterial by fibroblasts and cytotoxicity of the biomaterial to fibroblasts. The interaction between fibroblasts and the derivative fibronectin biomaterial was visualized using time-lapse photography. The deriv...Continue Reading

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Citations

May 9, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gabriella Meier Bürgisser, Johanna Buschmann
Feb 26, 2013·Blood Reviews·Thierry BurnoufMirjana Radosevic
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Jan 31, 2019·Journal of Cellular Physiology·Sanaz Naghavi AlhosseiniMasoud Mozafari

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