Shear-Driven Instabilities of Membrane Tubes and Dynamin-Induced Scission

Physical Review Letters
Sami C Al-IzziMatthew S Turner

Abstract

Motivated by the mechanics of dynamin-mediated membrane tube fission, we analyze the stability of fluid membrane tubes subjected to shear flow in azimuthal direction. We find a novel helical instability driven by the membrane shear flow which results in a nonequilibrium steady state for the tube fluctuations. This instability has its onset at shear rates that may be physiologically accessible under the action of dynamin and could also be probed using in vitro experiments on membrane nanotubes, e.g., using magnetic tweezers. We discuss how such an instability may play a role in the mechanism for dynamin-mediated membrane tube fission.

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P G Saffman, M Delbrück
Nov 1, 1973·Zeitschrift Für Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie·W Helfrich
Oct 1, 1996·Molecular Membrane Biology·S J McClure, P J Robinson
Oct 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·W Cai, T C Lubensky
Aug 22, 1994·Physical Review Letters·W Cai, T C Lubensky
Apr 24, 1995·Physical Review Letters·P NelsonU Seifert
Jul 2, 1999·Biophysical Journal·M M Kozlov
Jun 13, 2002·Physical Review Letters·Imre DerényiJacques Prost
Sep 28, 2004·Physical Review Letters·Pierre Sens
Feb 8, 2005·Biophysical Journal·Damien CuvelierPierre Nassoy
May 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·F Brochard-WyartP Nassoy
Mar 16, 2007·Physical Review Letters·Jean-Baptiste Fournier, Paolo Galatola
Aug 1, 2007·Physical Biology·Basarab G HosuGabor Forgacs
Sep 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin LenzJean-François Joanny
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Marino Arroyo, Antonio Desimone
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Aurélien RouxPatricia Bassereau
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Mark L Henle, Alex J Levine
Nov 30, 2010·Biophysical Journal·Sandrine MorlotAurélien Roux
Oct 23, 2012·Biomechanics and Modeling in Mechanobiology·Padmini RangamaniDavid J Steigmann
Apr 9, 2014·Nature Communications·Ayako YamadaPatricia Bassereau
May 27, 2014·Physical Review Letters·Tristan T HormelRaghuveer Parthasarathy
Nov 7, 2014·F1000prime Reports·Aurélien Roux
Nov 21, 2015·Physical Review Letters·Richard G Morris, Matthew S Turner
Nov 4, 2016·The EMBO Journal·Bruno AntonnySandra Schmid
Dec 8, 2016·Biophysical Journal·Zachary A McDarghMarkus Deserno
Jun 27, 2017·Cell·Mijo SimunovicAndrew Callan-Jones
Jan 20, 2018·Physical Review. E·Amaresh SahuKranthi K Mandadapu
Feb 8, 2018·Nature Reviews. Molecular Cell Biology·Marko Kaksonen, Aurélien Roux
Feb 14, 2018·Traffic·Zachary A McDargh, Markus Deserno
Jun 25, 2020·Physical Review. E·Amaresh SahuKranthi K Mandadapu

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Citations

Jul 17, 2021·Seminars in Cell & Developmental Biology·Sami C Al-Izzi, Richard G Morris

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