Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells

Cell Communication & Adhesion
Brenda R KwakPaolo Meda

Abstract

Hemodynamic forces play a critical role in atherogenesis, as evidenced by the focal pattern of development of atherosclerotic lesions. Whereas disturbed flow in the branches and curved regions of large arteries is proatherogenic, laminar flow in the straight parts of vessels is atheroprotective. In addition, hypertension and age-related changes in arterial stiffness are important risk factors of the disease. Hemodynamic forces induce various changes in the structure and function of vascular endothelium, many of which reflect alterations in gene expression. Endothelial cells are linked by gap junctions, which facilitate the propagation of electrical and chemical signals along the vascular wall. Using an in vitro perfusion system, we investigated the effects of pulsed unidirectional and oscillatory flows in combination with different levels of hydrostatic pressure and circumferential stretch on the expression of Cx43 in endothelial cells. Our results show that shear stress and circumferential stretch, but not pressure, modulate the expression of Cx43. In view of the distribution of this protein along the vascular tree, our findings provide new insights into the role of mechanical forces on gap junctional communication in regions ...Continue Reading

References

Feb 1, 1991·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·Y TardyM Arditi
Dec 1, 1989·The Journal of Cell Biology·M S PepperP Meda
Jan 15, 1982·Experientia·L G SpagnoliG Palmieri
Feb 18, 1997·Circulation·J A HaefligerP Meda
Apr 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H I YehN J Severs
Mar 12, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K ZiambarasR Civitelli
Apr 30, 1998·Circulation Research·D B CowanB L Langille
Jan 14, 1999·The New England Journal of Medicine·R Ross
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·N DePaolaD C Polacek
Jul 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·J A HaefligerD Hayoz
Jan 13, 2000·Biochemical and Biophysical Research Communications·T L WangH Chang
Jan 29, 2000·Histochemistry and Cell Biology·M J van Kempen, H J Jongsma
Jun 24, 2000·Annals of the New York Academy of Sciences·M A GimbroneG Garcia-Cardeña
Aug 19, 2000·Circulation Research·J ZhuangA G Kléber
Sep 16, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H I YehC H Tsai
Sep 23, 2000·Nature·A J Lusis
Mar 10, 2001·Cell·C K Glass, J L Witztum
Apr 11, 2001·Molecular Biology of the Cell·B R KwakP Meda
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y LiaoB R Duling
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Brenda R KwakFrançois Mach
Mar 20, 2002·Experimental Cell Research·Jacques-Antoine HaefligerPaolo Meda
May 7, 2002·Cell Biology International·Ernesto Oviedo-OrtaW Howard Evans
Dec 20, 2002·Nature·Peter Libby
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eliseo A EugenínJuan C Sáez
May 20, 2003·The Journal of Biological Chemistry·Corinne PellieuxPaolo Silacci
Dec 19, 2003·Cell Communication & Adhesion·Cindy W WongBrenda R Kwak
Oct 12, 2004·American Journal of Physiology. Cell Physiology·Li BaoGerhard Dahl
Nov 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mia M ThiDavid C Spray

❮ Previous
Next ❯

Citations

Oct 7, 2008·Antioxidants & Redox Signaling·Anne C BrissetBrenda R Kwak
Oct 4, 2008·Antioxidants & Redox Signaling·Xavier F Figueroa, Brian R Duling
Apr 25, 2013·Cardiovascular Research·Merlijn J MeensMario Delmar
Oct 17, 2009·Journal of Biomechanical Engineering·Qingping YaoHai-Chao Han
May 18, 2011·BMC Cell Biology·Chi-Young WangHung-I Yeh
Sep 2, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Chi-Jen ChangYu-Shien Ko
May 1, 2009·Seminars in Immunopathology·Sandrine MorelBrenda R Kwak
Jun 5, 2012·Journal of Molecular and Cellular Cardiology·Anna PfennigerBrenda R Kwak
Sep 8, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Tyler ThacherNikos Stergiopulos
Sep 16, 2010·European Journal of Clinical Investigation·Anna PfennigerBrenda R Kwak
Jun 8, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Massimo BolognesiDavid Sacerdoti
Jun 21, 2015·Cellular and Molecular Life Sciences : CMLS·Merlijn J MeensHeather S Duffy
Nov 12, 2013·The Veterinary Journal·Chia-Fang HoChi-Young Wang
Oct 30, 2016·Thrombosis and Haemostasis·Allyson Shook Ching SoonDavid Laurence Becker
Jun 3, 2018·Acta Physiologica·K PogodaU Pohl
Sep 18, 2009·Biomechanics and Modeling in Mechanobiology·Yong He, Sanjeev G Shroff
Mar 1, 2019·Clinical & Experimental Ophthalmology·Nikoleta TelliosCindy Hutnik
Dec 12, 2012·Annals of Biomedical Engineering·Jennifer M DolanHui Meng
Sep 22, 2017·Pharmacological Reviews·Luc LeybaertRainer Schulz
Mar 29, 2014·Pharmacological Reviews·Marie BillaudBrant E Isakson
Nov 8, 2014·Journal of Biomechanical Engineering·Caleb A DavisMichael Moreno
Apr 10, 2013·Pflügers Archiv : European journal of physiology·Eno E Ebong, Natacha Depaola
Sep 14, 2007·Annals of Medicine·Christos E Chadjichristos, Brenda R Kwak
Feb 7, 2009·Physiology·Laurent BurnierBrenda R Kwak
Mar 14, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Young Pil WangChan Beom Park
Oct 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Bernd J VorderwülbeckeAndreas Zakrzewicz
Jan 4, 2021·Cellular and Molecular Life Sciences : CMLS·Raghda RamadanLuc Leybaert
May 16, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Takayuki OkamotoMotomu Shimaoka
Jul 24, 2021·Advanced Healthcare Materials·Hyeonji YuJungwook Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Michael A Gimbrone, Guillermo Garcia-Cardena
Current Atherosclerosis Reports
Cameron J WorldBradford C Berk
© 2021 Meta ULC. All rights reserved