Shear stress and vascular remodeling: study of cardiac allograft coronary artery disease as a model of diffuse atherosclerosis

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Ernst WellnhoferE Fleck

Abstract

The assessment of remodeling in diffuse atherosclerosis by intravascular ultrasound is hampered by the lack of an appropriate reference segment. Transplant coronary artery disease is an accepted model of diffuse atherosclerosis. Flow-dependent remodeling is regulated by shear stress. Thus, normal levels of shear stress at baseline flow reflect adequate regulation and provide a functional assessment of flow-dependent remodeling. The approach was evaluated in 91 patients with transplant coronary artery disease and in 9 non-transplanted controls and 16 control transplant recipients. Quantitative coronary angiography, intracoronary ultrasound and intracoronary velocity studies were performed at baseline and after pharmacologic intervention. Calculated shear stress was compared between these groups and a sub-group with coronary angioplasty at follow-up (8 of 60 patients with control angiography after 23 +/- 8 months). The relation of shear stress to flow, diameter, flow/area ratio and endothelial function was analyzed. Normal shear stress was found in non-transplanted controls and transplant recipients without coronary artery disease. Patients with coronary angioplasty at follow-up had elevated shear stress and enhanced endothelial ...Continue Reading

References

Aug 1, 1988·Journal of the American College of Cardiology·S Z GaoS A Hunt
May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Dec 17, 1987·The New England Journal of Medicine
Apr 1, 1995·American Heart Journal·H O VenturaD D Stapleton
Nov 14, 1997·Journal of the American College of Cardiology·Y BirnbaumR J Siegel
Jul 8, 1999·The American Journal of Pathology·M A Gimbrone
Jul 10, 1999·Journal of the American College of Cardiology·K PethigA Haverich
Jul 21, 1999·Journal of Cardiovascular Electrophysiology·N A HerityA C Yeung
Mar 21, 2000·Ultrasound in Medicine & Biology·P DoriotP Chatelain
Jun 27, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J KobashigawaJ Tobis
Sep 7, 2000·Circulation·M R WardC Borst

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Citations

Feb 21, 2009·Annals of Biomedical Engineering·Leonid GoubergritsHans-Christian Hege
May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Carl AtkinsonMartin Goddard
Apr 18, 2008·Current Cardiology Reports·David Lin, Christopher M Kramer
May 19, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Ernst WellnhoferNicola E Hiemann
Nov 18, 2006·Expert Opinion on Pharmacotherapy·Javier SegoviaLuis Alonso-Pulpón
Mar 31, 2005·Journal of Biomechanical Engineering·Wei ZhangGhassan S Kassab
Jun 9, 2017·Current Hypertension Reports·Rolf F BarthSergey V Brodsky

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