PMID: 12780506Jun 5, 2003Paper

Shear stress related blood damage in laminar couette flow

Artificial Organs
Reinhard PaulH Reul

Abstract

Artificial organs within the blood stream are generally associated with flow-induced blood damage, particularly hemolysis of red blood cells. These damaging effects are known to be dependent on shear forces and exposure times. The determination of a correlation between these flow-dependent properties and actual hemolysis is the subject of this study. For this purpose, a Couette device has been developed. A fluid seal based on fluorocarbon is used to separate blood from secondary external damage effects. The shear rate within the gap is controlled by the rotational speed of the inner cylinder, and the exposure time by the amount of blood that is axially pumped through the device per given time. Blood damage is quantified by the index of hemolysis (IH), which is calculated from photometric plasma hemoglobin measurements. Experiments are conducted at exposure times from texp=25 - 1250 ms and shear rates ranging from tau=30 up to 450 Pa ensuring Taylor-vortex free flow characteristics. Blood damage is remarkably low over a broad range of shear rates and exposure times. However, a significant increase in blood damage can be observed for shear stresses of tau>or= 425 Pa and exposure times of texp>or= 620 ms. Maximum hemolysis within ...Continue Reading

References

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Citations

Feb 16, 2013·Pediatric Cardiology·Amy L ThrockmortonWilliam Moskowitz
Dec 20, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Osamu MaruyamaToru Masuzawa
Nov 12, 2005·Biomechanics and Modeling in Mechanobiology·Mauro GrigioniCostantino Del Gaudio
Apr 27, 2007·Annals of Biomedical Engineering·Nathan J Quinlan, Patrick N Dooley
Dec 1, 2007·Annals of Biomedical Engineering·Liang GeAjit P Yoganathan
Feb 8, 2011·Annals of Biomedical Engineering·Linden A DownEdgar A O'Rear
May 25, 2011·Annals of Biomedical Engineering·Mikhail LaraKerem Pekkan
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Jun 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jonathan T Butcher, Robert M Nerem
Jun 30, 2009·Seminars in Dialysis·Hans-Dietrich Polaschegg
Oct 27, 2004·Artificial Organs·André Garon, Marie-Isabelle Farinas
Apr 16, 2004·Artificial Organs·Paul S Malchesky
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Apr 18, 2007·Artificial Organs·Ihsan BakirBart Meyns
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Jun 29, 2011·Computer Methods in Applied Mechanics and Engineering·Jaewook NamMatteo Pasquali

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