Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen

Archives of Oral Biology
R A P M PereraC S P Tsang

Abstract

Epstein Barr virus (EBV) is one of the ubiquitous viral carcinogens found in humans and successfully infects more than 90% of the world population. The spectrum of EBV-related pathology ranges from asymptomatic primary infection to grave B- and T-cell malignancies. EBV triggers lymphoproliferative disorders after allogeneic stem cell transplantation, which contributes to higher mortality rates. Although the transmission of EBV primarily occurs from an infected host to a naive host through viral shedding from the oropharynx, increasing evidence points to considerable amount of shedding in other anatomical sites such as cervix, anal mucosa, breast milk and respiratory tract. It is impossible to eradicate the prevalence of EBV-related malignancies and other pathologies without preventing viral shedding. However, a detail analysis of the multifaceted nature of EBV shedding is not available in the literature. Thus, this review focuses on elucidating the key elements of the shedding dynamics of this carcinogenic virus.

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Citations

Aug 19, 2011·Journal of Virology·Michael L FreemanMarcia A Blackman
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Luciana Cristina Fagundes GequelinCarmem M Bonfim
Sep 8, 2016·International Journal of Cancer. Journal International Du Cancer·Octavia RamayantiJaap M Middeldorp
Oct 18, 2019·Frontiers in Immunology·Heather M LongGraham S Taylor

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