PMID: 11906839Mar 22, 2002Paper

Shedding light on proteins, nucleic acids, cells, humans and fish

Mutation Research
R B Setlow

Abstract

I was trained as a physicist in graduate school. Hence, when I decided to go into the field of biophysics, it was natural that I concentrated on the effects of light on relatively simple biological systems, such as proteins. The wavelengths absorbed by the amino acid subunits of proteins are in the ultraviolet (UV). The wavelengths that affect the biological activities, the action spectra, also are in the UV, but are not necessarily parallel to the absorption spectra. Understanding these differences led me to investigate the action spectra for affecting nucleic acids, and the effects of UV on viruses and cells. The latter studies led me to the discovery of the important molecular nature of the damages affecting DNA (cyclobutane pyrimidine dimers) and to the discovery of nucleotide excision repair. Individuals with the genetic disease xeroderma pigmentosum (XP) are extraordinarily sensitive to sunlight-induced skin cancer. The finding, by James Cleaver, that their skin cells were defective in DNA repair strongly suggested that DNA damage was a key step in carcinogenesis. Such information was important for estimating the wavelengths in sunlight responsible for human skin cancer and for predicting the effects of ozone depletion on...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R W HartA D Woodhead
Sep 1, 1979·The Journal of Investigative Dermatology·L B Taichman, R B Setlow
Feb 1, 1979·Photochemistry and Photobiology·P M AcheyR B Setlow
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S M D'Ambrosio, R B Setlow
Jan 1, 1975·Basic Life Sciences·C S Rupert
Jan 1, 1976·Mechanisms of Ageing and Development·R W Hart, R B Setlow
Jun 14, 1991·Science·S B Prusiner
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Shima, A Shimada
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowE Grist
May 1, 1987·Genetics·R B Setlow
Jan 1, 1987·Environmental Mutagenesis·R B Setlow
May 1, 1966·Journal of Molecular Biology·R B Setlow, W L Carrier
Jun 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R W Hart, R B Setlow
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R B Setlow
Dec 1, 1968·Photochemistry and Photobiology·R B Setlow
May 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowF J Bollum
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·S Y WangC S Rupert
Nov 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowW L Carrier
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J D ReganR D Ley
Apr 1, 1968·Biophysical Journal·B M SutherlandR B Setlow
Dec 29, 1967·Science·B M SutherlandR B Setlow
Nov 1, 1981·Journal of Virology·D B YaroshR B Setlow
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowA D Woodhead
Jan 1, 1993·Environmental and Molecular Mutagenesis·F E AhmedN Setlow
Nov 13, 1996·Mechanisms of Ageing and Development·G A Cortopassi, E Wang
Oct 28, 1999·The Journal of Investigative Dermatology. Symposium Proceedings·R B Setlow

❮ Previous
Next ❯

Citations

Mar 11, 2004·DNA Repair·Richard B Setlow
May 27, 2005·Mutation Research·Richard B Setlow
Mar 21, 2008·Photochemistry and Photobiology·Gary M Halliday, J Guy Lyons
Dec 15, 2005·Journal of Virology·David PeretzStanley B Prusiner
Jan 11, 2011·PloS One·Weijun LiuYong Wan
Sep 24, 2004·Biochemical and Biophysical Research Communications·Andrey NikiforovNikolai Tomilin
Nov 30, 2011·Seminars in Cutaneous Medicine and Surgery·Gary M HallidayDiona L Damian
Feb 18, 2018·Current Problems in Cancer·Babita SharmaAnjana Munshi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.