Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores

Chemical Society Reviews
Peter VerwilstJong Seung Kim

Abstract

Historically, in Alzheimer's disease research, a lot of attention has been paid to the development of highly selective fluorophores for beta amyloid plaques. With a shift in the understanding of the disease and the importance of a network of cross-talk interactions, the development of small-molecule fluorescent dyes with high selectivity for (hyperphosphorylated) tau protein aggregates in neurofibrillary tangles has been gaining increasing attention. Fluorescent dyes for the selective labelling of tau aggregates in histological AD brain sections have been described, spanning the entire visible range of the electromagnetic spectrum. Despite the relatively early stages of the development of the field, a large diversity in probe architectures has been reported. Importantly, a handful of near-infrared-emissive dyes have been described as well, and some of these have exhibited good pharmacological profiles, with a significant blood-brain-barrier permeability, and a demonstrated ability to label tau tangles in vivo in small-animal models of Alzheimer's disease and other tauopathies. The developments summarized in the current work are expected to aid the unravelling of the diverse set of players in the etiology of Alzheimer's disease....Continue Reading

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Citations

Aug 25, 2018·Chemical Society Reviews·Hong-Wen LiuWeihong Tan
May 28, 2019·Journal of Neuropathology and Experimental Neurology·Claire H StevensLezanne Ooi
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siyang DingYuning Hong
Nov 11, 2019·Acta Neuropathologica Communications·Maria Calvo-RodriguezBrian J Bacskai
Sep 25, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Mona-Lisa MalarteLaetitia Lemoine
Sep 10, 2020·Advanced Materials·Jin ZhouJong Seung Kim
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sascha G KellerYasuteru Urano
Jan 2, 2021·Frontiers in Molecular Neuroscience·Rocco PizzarelliSilvia Di Angelantonio
Feb 18, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Daniel RazanskyRuiqing Ni
Mar 12, 2021·ACS Chemical Neuroscience·Anastasiia A StepanchukPeter K Stys
Apr 6, 2021·ACS Omega·Chandra Mouli R MadhuranthakamPraveen P N Rao
Jun 7, 2021·Current Opinion in Chemical Biology·Marie Shimogawa, E James Petersson
Apr 21, 2020·Chemical Science·Yanyan ZhaoFranklin I Aigbirhio
Apr 12, 2019·Chemical Reviews·Bowen YangJianlin Shi
Sep 2, 2021·Biomedical Engineering Letters·Jae Hyun KimKyo Seon Hwang

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Methods Mentioned

BETA
transgenic
fluorescence imaging
light scattering

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