Shedding of CD44 from PMA-differentiated U-937 cells is enhanced by treatment with mineral particles

Biochemical and Biophysical Research Communications
N TrabelsiY Pilatte

Abstract

In this report, we show that enhanced shedding of CD44 might contribute to the down-regulation of this receptor observed after phagocytosis of MnO2 particles by PMA-differentiated U-937. The apparent Mr of the soluble CD44 detected in culture supernatants was slightly lower than that of the membrane form suggesting that shedding resulted from proteolytic cleavage. Increased shedding of CD44 was also noted with other mineral particles (chrysotile and DQ12) but to a lower extent whereas some (TiO2 and amosite) had no effect on this process. These results indicate that shedding enhancement was particle-specific rather than a general consequence of phagocytosis. The ability of the particles to enhance CD44 shedding was not directly dependent on their cytotoxic potency. Different patterns of reactivity were noted with CD11b, suggesting that the underlying mechanisms are specific.

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Dec 24, 1997·Environmental Health Perspectives·N TrabelsiY Pilatte

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Citations

Nov 24, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Mayumi Hidaka, Kenji Fukuzawa
Apr 21, 2016·Toxicology and Applied Pharmacology·Timothy N PerkinsNiki L Reynaert

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