Shedding pounds after going under the knife: guts over glory-why diets fail.

Nature Medicine
Rachel Larder, Stephen O'Rahilly

Abstract

Losing weight can pose a challenge, but how to avoid putting those pounds back on can be a real struggle. A major health problem for obese people is that diseases linked to obesity, such as type 2 diabetes and cardiovascular disease, put their lives at risk, even in young individuals. Although bariatric surgery-a surgical method to reduce or modify the gastrointestinal tract-was originally envisioned for the most severe cases of obesity, evidence suggests that the benefit of this procedure may not be limited to the staggering weight loss it causes. Endogenous factors released from the gut, and modified after surgery, may explain why bariatric surgery can be beneficial for obesity-related diseases and why operated individuals successfully maintain the weight loss. In 'Bedside to Bench,' Rachel Larder and Stephen O'Rahilly peruse a human study with dieters who regained weight despite a successful diet. Appetite-regulating hormones in the gut may be responsible for this relapse in the long term. In 'Bench to Bedside,' Keval Chandarana and Rachel Batterham examine how two different methods of bariatric surgery highlight the relevance of gut-derived hormones not only in inducing sustained weight loss but also in improving glucose ho...Continue Reading

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Citations

Sep 25, 2012·Current Atherosclerosis Reports·Marco Castagneto, Geltrude Mingrone
Nov 6, 2013·Annual Review of Physiology·Sean Manning, Rachel L Batterham
Jan 16, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Y-H YuR Peterli
Mar 3, 2015·The Journal of Clinical Investigation·Sean ManningRachel L Batterham
Mar 18, 2017·Science·Yingfeng DengPhilipp E Scherer
Aug 26, 2017·Nutrition and Health·Gisele FariasAlexandre Coutinho Teixeira de Freitas

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