Shedding pounds after going under the knife: metabolic insights from cutting the gut.

Nature Medicine
Keval Chandarana, Rachel L Batterham

Abstract

Losing weight can pose a challenge, but how to avoid putting those pounds back on can be a real struggle. A major health problem for obese people is that diseases linked to obesity, such as type 2 diabetes and cardiovascular disease, put their lives at risk, even in young individuals. Although bariatric surgery-a surgical method to reduce or modify the gastrointestinal tract-was originally envisioned for the most severe cases of obesity, evidence suggests that the benefit of this procedure may not be limited to the staggering weight loss it causes. Endogenous factors released from the gut, and modified after surgery, may explain why bariatric surgery can be beneficial for obesity-related diseases and why operated individuals successfully maintain the weight loss. In 'Bedside to Bench,' Rachel Larder and Stephen O'Rahilly peruse a human study with dieters who regained weight despite a successful diet. Appetite-regulating hormones in the gut may be responsible for this relapse in the long term. In 'Bench to Bedside,' Keval Chandarana and Rachel Batterham examine how two different methods of bariatric surgery highlight the relevance of gut-derived hormones not only in inducing sustained weight loss but also in improving glucose ho...Continue Reading

References

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Citations

Sep 29, 2012·The Journal of Endocrinology·Alessandro Pocai
Nov 6, 2013·Annual Review of Physiology·Sean Manning, Rachel L Batterham
Oct 30, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A R RamzyP K Chelikani
Apr 12, 2016·Frontiers in Endocrinology·Azizun NessaKhalid Hussain
Feb 25, 2015·BioMed Research International·Antje Damms-MachadoStephan C Bischoff
Jul 18, 2015·Journal of Diabetes Research·Christian Ferdinand JurowichHermann Koepsell
Mar 18, 2015·Journal of Vascular and Interventional Radiology : JVIR·Clifford R WeissAravind Arepally
May 20, 2015·BMC Biology·James Cantley, Frances M Ashcroft
Sep 21, 2013·Molecular Metabolism·Keval ChandaranaRachel L Batterham
Apr 22, 2014·Molecular Metabolism·Alessandro Pocai
Apr 1, 2015·Future Medicinal Chemistry·Luca Costantino, Daniela Barlocco
Jan 26, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C BuntJ Krakoff
Oct 5, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Charles PirletOlivier F Bertrand
Jul 28, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Frank Wilczek
Feb 12, 2017·Cardiovascular and Interventional Radiology·Jae Min KimDo Yun Lee
May 15, 2021·TheScientificWorldJournal·Athanasios PantelisDimitris P Lapatsanis

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