PMID: 8599183Oct 1, 1995Paper

Sheep mortality associated with paralytic shellfish poisons from the cyanobacterium Anabaena circinalis

Toxicon : Official Journal of the International Society on Toxinology
Andrew P NegriM Hindmarsh

Abstract

This is the first report of sheep mortalities associated with paralytic shellfish poisons (PSPs) from the cyanobacterium Anabaena circinalis Rabenhorst. Fourteen sheep died within 150 m of a farm dam containing a dense bloom of A. circinalis. Extracts from both the cyanobacterium and small intestine from a dead ewe were analysed by high-performance liquid chromtography (HPLC) and found to contain PSPs. The toxin profiles of the cyanobacterium contained a high proportion of C-toxins (70%), whereas toxins in the small intestine content were dominated by gonyautoxin 5 (87%). This observation could be explained by desulfation of the C-toxins in the gut of the sheep. The LD100 of bloom material calculated from HPLC data was consistent with mouse bioassay data (12-25 mg/kg). The symptoms of affected sheep, mouse bioassay data, coupled with HPLC analysis of toxins from the bloom samples and the intestine contents, and the absence of other cyanobacterial alkaloid toxins, indicate that PSPs were responsible for the deaths of the sheep.

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Citations

Mar 20, 2010·Analytical and Bioanalytical Chemistry·Rómulo AráozJordi Molgó
May 1, 2005·Environmental Toxicology and Pharmacology·M C C BatoréuS Franca
Jun 20, 2000·Toxicon : Official Journal of the International Society on Toxinology·P PereiraY Oshima
Aug 2, 2001·Toxicon : Official Journal of the International Society on Toxinology·V VasconcelosF O Teles
Oct 16, 2001·Toxicon : Official Journal of the International Society on Toxinology·P T OrrC L Orr
Apr 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Philip T OrrKerry Berger
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N BouaíchaY Levi
Oct 12, 2010·Applied and Environmental Microbiology·Jamal Al-TebrinehBrett A Neilan
Nov 30, 2013·Marine Drugs·Fan ZhangZhonghua Liu
Aug 30, 2008·Marine Drugs·Jonathan R DeedsSara Watt Longan
Nov 10, 2011·Toxins·Elisabete ValérioRogério Tenreiro
Mar 23, 2004·Toxicon : Official Journal of the International Society on Toxinology·Hong Nong ChouChih Yu Chen
Jan 21, 2014·Current Problems in Pediatric and Adolescent Health Care·Chelsea A Weirich, Todd R Miller
Feb 23, 2011·Ecotoxicology and Environmental Safety·François PerreaultWilliam Gerson Matias
Dec 29, 2009·Toxicon : Official Journal of the International Society on Toxinology·Stacey M Etheridge
Aug 4, 2009·Toxicon : Official Journal of the International Society on Toxinology·Stjepko GolubicDominique Laurent
Aug 8, 2009·Toxicon : Official Journal of the International Society on Toxinology·Rómulo AráozNicole Tandeau de Marsac
May 14, 2005·Environmental Toxicology·Jarkko RapalaLiisa Lepistö
Jan 13, 2011·Toxicon : Official Journal of the International Society on Toxinology·Francine M J SmithSally Gaw
May 28, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·H M LiyanageL Guneratne
Oct 8, 2016·Environmental Toxicology and Pharmacology·Katie O'NeillAndrew Humpage
Oct 14, 2017·Marine Drugs·Lorena M Durán-Riveroll, Allan D Cembella
Apr 19, 2020·The Veterinary Record·Nicola BatesAndrew D Turner
Aug 12, 2018·Toxins·Natalia VilariñoLuis M Botana
Jul 28, 2019·Archives of Toxicology·Zorica SvirčevGeoffrey A Codd
Nov 25, 2018·Toxicon : Official Journal of the International Society on Toxinology·Paul M D'AgostinoSusanna A Wood

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