Shell-crosslinked zein nanocapsules for oral codelivery of exemestane and resveratrol in breast cancer therapy

Nanomedicine
Ahmed O ElzoghbyNazik A Elgindy

Abstract

Oral administration of exemestane (EXM) and resveratrol (RES) for breast cancer therapy has been limited by their poor solubility and low permeability. In this study, these issues were tackled using zein nanocapsules (ZNCs) for oral EXM/RES codelivery combining drug solubilization within oily core and resistance to digestion via hydrophobic protein shell. Furthermore, higher oral stability and sustained release could be enabled by glutaraldehyde crosslinking of zein shell. EXM/RES-ZNCs showed enhanced cytotoxicity against MCF-7 and 4T1 breast cancer cells compared with free drug combination with higher selectivity to cancer cells rather than normal fibroblasts. In vivo, crosslinked EXM/RES-ZNCs markedly reduced the percentage increase of Ehrlich ascites mammary tumor volume in mice by 2.4-fold compared with free drug combination.

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Citations

Jan 31, 2020·Expert Opinion on Drug Delivery·Dina A HafezAhmed O Elzoghby
Aug 22, 2020·Expert Opinion on Drug Delivery·Islam A Hassanin, Ahmed O Elzoghby
Jan 19, 2020·Pharmaceutics·Silvia VociDonato Cosco
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Mona A AbdelmoneemAhmed O Elzoghby
Mar 4, 2021·Cancer Reports·Manjusha AnnajiR Jayachandra Babu
Mar 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mardi M Algandaby, Majid M Al-Sawahli
Aug 21, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kholod A ElhasanyAhmed O Elzoghby
Jul 1, 2021·Nanomedicine·Ahmed S AbdElhamidAhmed O Elzoghby
Jul 14, 2021·Expert Opinion on Drug Delivery·Doaa M AnwarAhmed O Elzoghby
Aug 2, 2021·Methods : a Companion to Methods in Enzymology·Ana Luiza LimaGuilherme M Gelfuso
Jul 4, 2019·ACS Applied Materials & Interfaces·Mona A AbdelmoneemAhmed O Elzoghby
Jan 20, 2021·ACS Biomaterials Science & Engineering·Hadeer M AbdelazizMay S Freag

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Methods Mentioned

BETA
ELISA
differential scanning calorimetry
xenograft

Software Mentioned

Excel add inn
GraphPad
Graphpad Instat
Excel add - inn
Prism
Agilent ChemStation

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