Shell-Sheddable Poly(N-2-hydroxypropyl methacrylamide) Polymeric Micelles for Dual-Sensitive Release of Doxorubicin

Macromolecular Rapid Communications
Jiajing ZhangZhihua Gan

Abstract

Poly(ethylene glycol) (PEG) shell-sheddable micelles are proved to be effective tools for rapid intracellular drug delivery. However, some adverse factors, such as the potential immunogenicity and the accelerated blood clearance, might be accompanied with the traditional PEG sheddable micelles. Here, a poly(N-2-hydroxypropyl methacrylamide) (PHPMA) sheddable block copolymer containing disulfide bonds on the main chain is prepared to form pH- and reduction-dual-responsive micelles. The most optimal synthetic route of the block copolymer is selected from three potential pathways. Doxorubicin is loaded via an acid-labile hydrazone bond to achieve high drug loading content and to prevent premature drug release. As expected, as-prepared shell-sheddable micelles exhibit faster intracellular drug release and more satisfactory in vitro anticancer efficacy than the nonsheddable counterpart did. This design provides a feasible guideline for the efficient synthesis of similar shell-sheddable micelles consisting of PHPMA coatings.

References

Mar 19, 2002·Advanced Drug Delivery Reviews·Yoshinori Kakizawa, Kazunori Kataoka
Mar 7, 2003·Nature·Sean D Conner, Sandra L Schmid
Nov 17, 2006·Pharmaceutical Research·V P Torchilin
Nov 28, 2006·Advanced Drug Delivery Reviews·Dirk Schmaljohann
Jun 7, 2007·Pharmaceutical Research·Birgit RombergGert Storm
Jun 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·C J F RijckenC F van Nostrum
Dec 18, 2007·International Journal of Pharmaceutics·Tatsuhiro Ishida, Hiroshi Kiwada
Feb 10, 2009·Biomaterials·Fenghua MengZhiyuan Zhong
Jul 28, 2009·Pharmaceutical Research·Tsutomu IshiharaTohru Mizushima
Mar 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shyh-Dar Li, Leaf Huang
May 23, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Matthias BarzMaría J Vicent
Nov 17, 2015·Journal of the American Chemical Society·Chunyang SunJun Wang
Jan 26, 2016·Advanced Drug Delivery Reviews·Aaron C Anselmo, Samir Mitragotri
May 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yaqin ZhuZhiyuan Zhong
Feb 7, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yaqin ZhuZhiyuan Zhong

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Citations

May 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Guangping YuShengsong Tang
Nov 18, 2020·ACS Applied Materials & Interfaces·Shengyu ZhangHongyan Zhu

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