Shen-fu injection attenuates postresuscitation lung injury in a porcine model of cardiac arrest

Resuscitation
Ming-Yue ZhangChunsheng Li

Abstract

To investigate the effects of Shen-Fu injection (SFI) on postresuscitation lung injury in a porcine model of cardiac arrest. Twenty-four anaesthetised male Landrace pigs were subjected to 4 min of untreated ventricular fibrillation (VF), followed by standard cardiopulmonary resuscitation. Sixteen successfully resuscitated pigs were randomised into two groups (eight pigs per group); one group received an SFI infusion and the other group received a normal saline infusion, at an infusion rate of 0.24 mg/min from 15 min after the return of spontaneous circulation (ROSC) until 6h after ROSC. Oxygenation index, respiratory index, oxygen delivery, oxygen consumption, oxygen extraction, dynamic lung compliance, airway resistance, external vascular lung water index, and pulmonary vascular permeability index at 15 min, 30 min, 1h, 2h, 4h, and 6h after ROSC were all worse than baseline in the saline group, and were all better in the SFI group than in the saline group. The pulmonary protective effects of SFI were further confirmed by histopathological and ultrastructural observations of lung tissue. SFI infusion resulted in lower apoptosis index, caspase-3 protein expression, and malondialdehyde content of lung tissue after ROSC, and incre...Continue Reading

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Citations

Sep 26, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qian Zhang, Chunsheng Li
Jan 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Li-Juan YangYu-Fang Yuan
Feb 8, 2016·The American Journal of Emergency Medicine·Qin YinChunsheng Li
May 21, 2013·Critical Care Medicine·Shuo Wang, Chun-Sheng Li
Jun 24, 2015·The American Journal of Emergency Medicine·Wan WuLi-Quan Huang
Dec 17, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Wei GuChunSheng Li
Jul 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yi LiXueZhong Yu
Sep 12, 2016·Chinese Journal of Integrative Medicine·Qin YinChun-Sheng Li
Sep 26, 2020·International Journal of Clinical Pharmacy·Can WangXuansheng Ding
Oct 17, 2017·Frontiers in Medicine·Takeshi Wada

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