Abstract
Tumor cells, especially drug-resistant cells, predominately support growth by glycolysis even under the condition of adequate oxygen, which is known as the Warburg effect. Glucose metabolism reprogramming is one of the main factors causing tumor resistance. Previous studies on Shenmai injection (SMI), a Chinese herbal medicine, have shown enhanced efficacy in the treatment of tumors in combination with chemotherapy drugs, but the mechanism is not clear. In this study, we investigated the effect of SMI combined with cisplatin on cisplatin-resistant lung adenocarcinoma A549/DDP cells. Our results showed that cisplatin-resistant A549/DDP cells exhibited increased glucose consumption, lactate production, and expression levels of key glycolytic enzymes, including hexokinase 2 (HK2), pyruvate kinase M1/2 (PKM1/2), pyruvate kinase M2 (PKM2), glucose transporter 1 (GLUT1), and lactate dehydrogenase A (LDHA), compared with cisplatin-sensitive A549 cells. SMI combined with cisplatin in A549/DDP cells, led to significantly lower expression levels of key glycolytic enzymes, such as HK2, PKM1/2, GLUT1, and pyruvate dehydrogenase (PDH). In addition, we found that the combination of SMI and cisplatin could inhibit cell proliferation and promo...Continue Reading
References
Sep 6, 2011·Oncogene·L GalluzziG Kroemer
Aug 2, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Lin WangJie Cao
Oct 22, 2014·Molecular Medicine Reports·Xiangyong LiLei Song
Aug 21, 2015·World Journal of Gastroenterology : WJG·Yan-Ling ChenBayasi Guleng
May 26, 2016·Molecular Medicine Reports·Jiaxin FuYonggang Tian
Nov 22, 2016·Acta Pharmacologica Sinica·Wen-Yue LiuFang Zhou
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Forest H AndrewsTatiana G Kutateladze
Feb 6, 2017·BioMed Research International·Ning YuChun Wang
Mar 6, 2017·Molecular Medicine Reports·Xueyan ZhangHulai Wei
Apr 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Priyanka MokashiNancy Pandita
Apr 30, 2017·PloS One·Qian ZhouXiumei Gao
May 23, 2017·Nature Communications·Prabir K ChakrabortyPriyabrata Mukherjee
Sep 10, 2017·Journal of Experimental & Clinical Cancer Research : CR·Xiaomin FengZhimin He
Dec 17, 2017·The International Journal of Biochemistry & Cell Biology·Xiao-Yan ZhangCong-Jian Xu
Mar 21, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yuanyuan ZhouLe Zhao
Mar 29, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yen-Hsiu YehTsai-Kun Li
Apr 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing-Jing MouFu-Xiang Zhou
Sep 4, 2018·Cell Metabolism·Maria ApicellaSimona Corso
Sep 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chuanyao ChengYanru Zhang
Sep 30, 2018·Drug Development Research·Tie FangXianjiang Wu
Oct 30, 2018·Neuroreport·Weiyi HuangTao Huang
Nov 27, 2018·Journal of Cellular Biochemistry·Yitong ZhouLudong Tan
Apr 7, 2020·Pharmaceutical Biology·Lin YangZhenqiang You