"Shepherd's crook" neurons drive and synchronize the enhancing and suppressive mechanisms of the midbrain stimulus selection network

Proceedings of the National Academy of Sciences of the United States of America
Florencia Garrido-CharadGonzalo Marín

Abstract

The optic tectum (TeO), or superior colliculus, is a multisensory midbrain center that organizes spatially orienting responses to relevant stimuli. To define the stimulus with the highest priority at each moment, a network of reciprocal connections between the TeO and the isthmi promotes competition between concurrent tectal inputs. In the avian midbrain, the neurons mediating enhancement and suppression of tectal inputs are located in separate isthmic nuclei, facilitating the analysis of the neural processes that mediate competition. A specific subset of radial neurons in the intermediate tectal layers relay retinal inputs to the isthmi, but at present it is unclear whether separate neurons innervate individual nuclei or a single neural type sends a common input to several of them. In this study, we used in vitro neural tracing and cell-filling experiments in chickens to show that single neurons innervate, via axon collaterals, the three nuclei that comprise the isthmotectal network. This demonstrates that the input signals representing the strength of the incoming stimuli are simultaneously relayed to the mechanisms promoting both enhancement and suppression of the input signals. By performing in vivo recordings in anesthetiz...Continue Reading

References

Jan 1, 1976·Vision Research·B J Frost, D E DiFranco
Mar 1, 1991·The Journal of Comparative Neurology·M Remy, O Güntürkün
Apr 1, 1989·Trends in Neurosciences·P DeanG W Westby
Jul 15, 1987·The Journal of Comparative Neurology·M I Sereno, P S Ulinski
Mar 21, 1997·Science·R R de Ruyter van SteveninckW Bialek
Apr 16, 1999·Nature Neuroscience·D K LeeJ Braun
Mar 21, 2001·Nature Reviews. Neuroscience·L Itti, C Koch
Oct 24, 2003·Brain, Behavior and Evolution·Zong-Xiang Tang, Shu-Rong Wang
Dec 25, 2003·The Journal of Comparative Neurology·Yuan WangHarvey J Karten
Jun 26, 2004·Annual Review of Neuroscience·John H Reynolds, Leonardo Chelazzi
Jul 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gonzalo MarínJuan Carlos Letelier
Oct 14, 2005·Progress in Brain Research·Paul J May
Jul 18, 2006·Trends in Cognitive Sciences·Jillian H Fecteau, Douglas P Munoz
Dec 8, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristin A MaczkoEric I Knudsen
Apr 10, 2007·Annual Review of Neuroscience·Eric I Knudsen
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gonzalo MarínJorge Mpodozis
Dec 23, 2009·Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Expérimentale·Douglas R W WylieAndrew N Iwaniuk
Jun 8, 2010·Nature Neuroscience·Ali AsadollahiEric I Knudsen
Sep 24, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alireza Soltani, Christof Koch
Feb 18, 2011·Journal of Neurophysiology·Devarajan SridharanEric I Knudsen
Jun 24, 2011·Current Opinion in Neurobiology·Shreesh P Mysore, Eric I Knudsen
Jan 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gonzalo J MarínJuan Carlos Letelier
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Mar 12, 2013·Nature Neuroscience·Shreesh P Mysore, Eric I Knudsen
May 21, 2013·Annual Review of Neuroscience·Richard J KrauzlisAlexandre Zénon
Jun 13, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Alex GoddardEric Knudsen
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Astra S BryantEric I Knudsen
Jul 20, 2016·The Journal of Comparative Neurology·Bertram NiederleitnerHarald Luksch
Nov 24, 2015·Annual Review of Vision Science·John H R Maunsell
Sep 30, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Richard J KrauzlisAnil Bollimunta
Oct 22, 2017·The Journal of Comparative Neurology·Katharina LischkaStefan Weigel
Feb 27, 2018·Frontiers in Neural Circuits·Tomas Vega-ZunigaHarald Luksch

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Citations

Feb 1, 2020·The Journal of Comparative Neurology·Eric I Knudsen
Sep 19, 2019·The Journal of Comparative Neurology·Máximo FernándezGonzalo J Marín
Aug 19, 2020·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Jiangtao WangLi Shi

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