Shexiang Baoxin Pills as an Adjuvant Treatment for Chronic Heart Failure: A System Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine : ECAM
Taiwei DongQian Xie

Abstract

Shexiang Baoxin pills (SXBXP), as a Traditional Chinese Medicine, are widely used for chronic heart failure in China. It is essential to systematically assess the efficacy and safety of SXBXP as an adjuvant treatment for chronic heart failure. Seven English and Chinese electronic databases (PubMed, Embase, Cochrane Library, CBM, Wanfang, VMIS, and CNKI) were searched from inception to July 2017. The Cochrane Risk of Bias tool was used to evaluate the methodological quality of eligible studies. Meta-analysis was performed by Review Manager 5.3. A total of 27 RCTs with 2637 participants were included in this review. Compared to conventional treatment, SXBXP combined with conventional treatment showed potent efficacy when it came to the total efficacy rate (OR, 3.88; 95% CI, 2.87, 5.26; P < 0.00001), B-type natriuretic peptide (BNP) (MD = -66.95; 95% CI, -108.57, -25.34; P = 0.002), N-terminal pro-brain natriuretic peptide (NT-ProBNP) (MD = -0.15; 95% CI, -0.21, -0.09; P < 0.00001), six-minute walking distance (6-MWD) (MD = 38.57; 95% CI, 28.47, 48.67; P < 0.00001), cardiac output (CO) (MD = 0.84; 95% CI, 0.68, 0.99; P < 0.00001), and Stroke Volume (SV) (MD = 7.43; 95% CI, 4.42, 10.44, P < 0.00001). The pooled subgroup analysis in...Continue Reading

References

Aug 14, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Dirk J LokPeter van der Meer
Apr 26, 2013·Circulation. Heart Failure·Paul A HeidenreichUNKNOWN Stroke Council
Mar 13, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Feb 13, 2016·Journal of Ginseng Research·Byong-Kyu ShinJeong Hill Park
Nov 20, 2016·International Journal of Cardiology·Ming-Yen TsaiYung-Hsiang Chen
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
May 2, 2017·BMC Medicine·Ofra Kalter-LeiboviciUNKNOWN Israel Heart Failure Disease Management Study (IHF-DMS) investigators

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Citations

Sep 1, 2019·Journal of Thrombosis and Thrombolysis·Yunzhen Hu, Jing Wang
Sep 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shan-Shan LinJing-Yuan Mao
Mar 12, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jun ShiWei Wang
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Qiao LiuPeifeng Wei

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