Shift-back of right into left hemisphere language dominance after control of epileptic seizures: evidence for epilepsy driven functional cerebral organization

Epilepsy Research
C HelmstaedterBernd Weber

Abstract

Atypical, i.e. right hemisphere language dominance is frequently observed in early onset left hemisphere epilepsies. In left mesial temporal lobe epilepsy, where eloquent cortex is not directly involved, it is a matter of debate, to which degree atypical language dominance is driven not only by morphological lesions but also by epileptic dysfunction, and whether atypical dominance is hardwired or not. Taking this as the background this study evaluated the hypothesis that epilepsy driven atypical dominancy might be reversible when seizures are successfully controlled. This was evaluated in patients with left mesial temporal lobe epilepsy, who were atypically language dominant by means of language fMRI before surgery, and became seizure free after left selective amygdalo-hippocampectomy. Three out of 53 consecutive atypically dominant patients with chronic epilepsy fulfilled these criteria. Postoperative follow-up language fMRI indicated reversal of right into left dominance in one patient going along with unexpected losses in verbal memory performance. The two other patients experienced unchanged or even enhancement of the pre-existing dominance pattern, going along with consistent postoperative performance changes in cognition....Continue Reading

References

Sep 30, 1977·Annals of the New York Academy of Sciences·T Rasmussen, B Milner
Dec 1, 1969·Journal of Comparative and Physiological Psychology·H Lansdell
Feb 1, 1994·Brain : a Journal of Neurology·M RegardT Landis
Nov 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·U GleissnerC E Elger
Nov 5, 1999·Brain : a Journal of Neurology·J A SpringerW M Mueller
Dec 2, 2000·Brain : a Journal of Neurology·S KnechtH Henningsen
Jun 25, 2003·Brain : a Journal of Neurology·J JanszkyA Ebner
May 29, 2004·Brain : a Journal of Neurology·Stefan Knecht

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Citations

Dec 9, 2008·Brain : a Journal of Neurology·J MbwanaW D Gaillard
Sep 10, 2010·Brain : a Journal of Neurology·Mahinda YogarajahJohn S Duncan
Mar 4, 2011·Neurology·W D GaillardW H Theodore
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Emilie CousinJean-François Le Bas
Dec 3, 2014·Neuroimaging Clinics of North America·Umair J Chaudhary, John S Duncan
Jul 28, 2012·Brain and Language·Madalina E TivarusJohn T Langfitt
Feb 27, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark Richardson
Feb 6, 2009·Annals of Neurology·Tibor AuerJozsef Janszky
Dec 25, 2010·Human Brain Mapping·Marko WilkeIngeborg Krägeloh-Mann
Mar 6, 2015·Reviews in the Neurosciences·Monica Baciu, Marcela Perrone-Bertolotti
Apr 30, 2014·Seizure : the Journal of the British Epilepsy Association·Gabriela PappStefan Evers
Nov 14, 2014·Brain : a Journal of Neurology·Caroline SkirrowTorsten Baldeweg
Jun 21, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Nathalie Tzourio-MazoyerMonica Baciu
Jun 4, 2010·Expert Review of Neurotherapeutics·Mark Richardson
Dec 11, 2020·Brain Sciences·Rūta MameniškienėDalius Jatužis
Jul 30, 2019·NeuroImage. Clinical·Natalie L VoetsPuneet Plaha

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