Abstract
Atypical, i.e. right hemisphere language dominance is frequently observed in early onset left hemisphere epilepsies. In left mesial temporal lobe epilepsy, where eloquent cortex is not directly involved, it is a matter of debate, to which degree atypical language dominance is driven not only by morphological lesions but also by epileptic dysfunction, and whether atypical dominance is hardwired or not. Taking this as the background this study evaluated the hypothesis that epilepsy driven atypical dominancy might be reversible when seizures are successfully controlled. This was evaluated in patients with left mesial temporal lobe epilepsy, who were atypically language dominant by means of language fMRI before surgery, and became seizure free after left selective amygdalo-hippocampectomy. Three out of 53 consecutive atypically dominant patients with chronic epilepsy fulfilled these criteria. Postoperative follow-up language fMRI indicated reversal of right into left dominance in one patient going along with unexpected losses in verbal memory performance. The two other patients experienced unchanged or even enhancement of the pre-existing dominance pattern, going along with consistent postoperative performance changes in cognition....Continue Reading
References
Sep 30, 1977·Annals of the New York Academy of Sciences·T Rasmussen, B Milner
Dec 1, 1969·Journal of Comparative and Physiological Psychology·H Lansdell
Aug 1, 1994·Brain : a Journal of Neurology·C HelmstaedterC E Elger
Feb 1, 1994·Brain : a Journal of Neurology·M RegardT Landis
Nov 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·U GleissnerC E Elger
Nov 5, 1999·Brain : a Journal of Neurology·J A SpringerW M Mueller
Dec 2, 2000·Brain : a Journal of Neurology·S KnechtH Henningsen
Mar 22, 2002·Epilepsia·Tatia M C LeeMarilyn Jones-Gotman
Jun 25, 2003·Brain : a Journal of Neurology·J JanszkyA Ebner
May 7, 2004·Brain : a Journal of Neurology·C HelmstaedterC E Elger
May 29, 2004·Brain : a Journal of Neurology·Stefan Knecht
Citations
Dec 9, 2008·Brain : a Journal of Neurology·J MbwanaW D Gaillard
Sep 10, 2010·Brain : a Journal of Neurology·Mahinda YogarajahJohn S Duncan
Mar 21, 2012·Epilepsia·Silvia B BonelliJohn S Duncan
Mar 4, 2011·Neurology·W D GaillardW H Theodore
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Emilie CousinJean-François Le Bas
Dec 3, 2014·Neuroimaging Clinics of North America·Umair J Chaudhary, John S Duncan
Jul 28, 2012·Brain and Language·Madalina E TivarusJohn T Langfitt
Apr 16, 2011·Brain and Cognition·G CarlssonU Stephani
Mar 17, 2010·Neuropsychologia·S KovacT Loddenkemper
Feb 27, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark Richardson
Dec 26, 2007·Epilepsy & Behavior : E&B·Kathrin WagnerAndreas Schulze-Bonhage
Feb 6, 2009·Annals of Neurology·Tibor AuerJozsef Janszky
Dec 25, 2010·Human Brain Mapping·Marko WilkeIngeborg Krägeloh-Mann
Mar 6, 2015·Reviews in the Neurosciences·Monica Baciu, Marcela Perrone-Bertolotti
Apr 30, 2014·Seizure : the Journal of the British Epilepsy Association·Gabriela PappStefan Evers
Dec 27, 2011·Epilepsy & Behavior : E&B·M Perrone-BertolottiM Baciu
Jul 16, 2013·Seizure : the Journal of the British Epilepsy Association·Xi ZhangYongjie Li
Nov 14, 2014·Brain : a Journal of Neurology·Caroline SkirrowTorsten Baldeweg
Jun 21, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Nathalie Tzourio-MazoyerMonica Baciu
Jul 10, 2016·Brain and Language·S BalterC R McDonald
Jun 4, 2010·Expert Review of Neurotherapeutics·Mark Richardson
May 23, 2019·Nature Communications·D Pacheco EstefanP F M J Verschure
Sep 9, 2020·PloS One·Carmen BarbaRenzo Guerrini
Dec 11, 2020·Brain Sciences·Rūta MameniškienėDalius Jatužis
Jul 30, 2019·NeuroImage. Clinical·Natalie L VoetsPuneet Plaha
Jul 4, 2021·NeuroImage. Clinical·Natalie L VoetsPuneet Plaha