PMID: 9783310Oct 23, 1998Paper

Shift from fetal to adult hemoglobin production in a preterm infant after exchange transfusion: a quantitative approach

Pediatric Hematology and Oncology
H E RefsumR Lindemann


To evaluate the quantitative aspects of the shift in production from fetal hemoglobin (HbF) to adult hemoglobin (HbA), the HbF and HbA mass were estimated in a preterm infant (gestational age 29 weeks) for 22 weeks after an exchange transfusion the second day of life, leading to an initial HbA% of 100. Up until the estimated time of delivery, the HbA mass declined continuously, at a rate corresponding to a survival time of the transfused HbA erythrocytes of 100 days, and the rise in total hemoglobin mass could be ascribed solely to a rise in the HbF mass. HbF% maximum was reached 3 weeks before HbF mass maximum, and, thus, the HbF% and HbA% time courses gave no basis for evaluation of the production/destruction balance of HbF and HbA erythrocytes. The applied quantitative approach seems to be a useful additional procedure for evaluating the switch from HbF to HbA production and for estimating HbA erythrocyte survival time in preterm infants.


Jan 1, 1979·Scandinavian Journal of Haematology·J G JonesC A Wardrop
Jan 24, 1985·Nature·W G WoodG Breckon
Jul 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·N Fogh-AndersenP D Wimberley
Aug 1, 1973·The Journal of Clinical Investigation·H Bard

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Jan 15, 2013·The Journal of Pediatrics·Jun-ichi NakashimaKazunari Kaneko

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