Shifts in cellular localization of moesin in normal oral epithelium, oral epithelial dysplasia, verrucous carcinoma and oral squamous cell carcinoma

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Hiroichi KobayashiShuníichiro Taniguchi

Abstract

Moesin, a member of ERM (ezrin/radixin/moesin) family, links actin filaments of cell surface structure to the cell membrane. The purpose of the study is to assess the shifts in cellular distribution of moesin in normal oral epithelium, oral epithelial dysplasia (OED), verrucous carcinoma (VC), and oral squamous cell carcinoma (OSCC). The expression of moesin was evaluated immunohistochemically in paraffin-embedded tissues of 59 specimens of OSCC, 35 specimens of OED, 17 specimens of VC, and five specimens of normal oral epithelium. In the normal oral epithelia, all specimens showed a pattern of membranous expression against the anti-moesin antibody in the basal layer cells. In the OED specimens, moesin was dominantly expressed in the cell membrane except for the cornified layer. In VC and OSCC specimens, almost the whole of the carcinoma cells were stained with anti-moesin antibody. However, in OSCC samples, moesin was markedly expressed increasingly in the cytoplasm and decreasingly in the cell membrane, as compared with OED and VC. In addition, there was a significant correlation between the pattern of moesin expression and tumor differentiation in OSCC. Our results suggest that it is useful to detect the moesin expression as...Continue Reading

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Citations

Jun 10, 2009·Clinical Oral Investigations·Paolo G ArduinoSergio Gandolfo
Jan 10, 2012·Head and Neck Pathology·Nicolas F SchlechtMichael B Prystowsky
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Martin KöbelSteffen Hauptmann
Aug 13, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jian-Jun XieEn-Min Li
Oct 9, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Ali-Farid SafiMatthias Kreppel
May 28, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Jen JouCheng-Wen Lin
Nov 12, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gayani PitiyageSaman Warnakulasuriya
Apr 29, 2016·International Journal of Oncology·Qian PengZhangui Tang
Jan 10, 2018·BMC Cancer·Francisco Bárbara Abreu BarrosDenise Tostes Oliveira
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroichi KobayashiShun'ichiro Taniguchi
Dec 25, 2019·Heliyon·Johnathan Abou-FadelJun Zhang

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